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Literature DB >> 422965

Effects of 4-aminopyridine in myasthenia gravis.

Abstract

A new drug, 4-aminopyridine, was prepared for use in humans and tested by repeated injections in six patients with myasthenia gravis. The drug caused improvement of muscle strength and neuromuscular transmission as demonstrated by clinical observations and repetitive electrical nerve stimulation. The drug was effective in cases without any other treatment as well as in cases undergoing treatment with anticholinesterases. It is concluded that 4-aminopyridine may be of value as a supplementary drug in the treatment of myasthenia gravis.

Entities: Chemical Disease Species

Mesh：

Substances：
Aminopyridines

Year: 1979 PMID： 422965 PMCID： PMC490183 DOI： 10.1136/jnnp.42.2.171

Source DB: PubMed Journal: J Neurol Neurosurg Psychiatry ISSN： 0022-3050 Impact factor: 10.154

11 in total

1. The mode of action of 4-aminopyridine and guanidine on transmitter release from motor nerve terminals.

Authors: H Lundh; S Thesleff
Journal: Eur J Pharmacol Date: 1977-04-21 Impact factor: 4.432

2. AN ELECTROPHYSIOLOGICAL INVESTIGATION OF NEUROMUSCULAR TRANSMISSION IN MYASTHENIA GRAVIS.

Authors: D ELMQVIST; W W HOFMANN; J KUGELBERG; D M QUASTEL
Journal: J Physiol Date: 1964-11 Impact factor: 5.182

3. 4-aminopyridine--a new drug tested in the treatment of Eaton-Lambert syndrome.

Authors: H Lundh; O Nilsson; I Rosén
Journal: J Neurol Neurosurg Psychiatry Date: 1977-11 Impact factor: 10.154

4. Effects of 4-aminopyridine on transmission in excitatory and inhibitory synapses in the spinal cord.

Authors: E Jankowska; A Lundberg; P Rudomin; E Sykova
Journal: Brain Res Date: 1977-11-11 Impact factor: 3.252

5. Effects of 4-aminopyridine on neuromuscular transmission.

Authors: H Lundh
Journal: Brain Res Date: 1978-09-22 Impact factor: 3.252

6. [Changes in transmitter release at frog neuromuscular junction induced by 4-aminopyridine].

Authors: J Molgo; M Lemeignan; P Lechat
Journal: C R Acad Hebd Seances Acad Sci D Date: 1975-11-24

7. Analysis of the effects of 4-amino pyridine on the lumbar cord of the cat. II. Modifications of certain spinal inhibitory phenomena, post-tetanic potentiation and dorsal root potentials.

Authors: M Lemeignan
Journal: Neuropharmacology Date: 1973-07 Impact factor: 5.250

8. Acetylcholine-induced channels and transmitter release at human endplates.

Authors: S G Cull-Candy; R Miledi; A Trautmann
Journal: Nature Date: 1978-01-05 Impact factor: 49.962

9. The effect of 4-aminopyridine on acetylcholine release.

Authors: E S Vizi; J van Dijk; F F Foldes
Journal: J Neural Transm Date: 1977 Impact factor: 3.575

10. Antagonism of the paralysis produced by botulinum toxin in the rat. The effects of tetraethylammonium, guanidine and 4-aminopyridine.

Authors: H Lundh; S Leander; S Thesleff
Journal: J Neurol Sci Date: 1977-05 Impact factor: 3.181

18 in total

1. A review of 29 incidents involving 4-aminopyridine in non-target species reported to the ASPCA Animal Poison Control Center.

Authors: Mary Kay McLean; Safdar Khan
Journal: J Med Toxicol Date: 2013-12

10. Aminopyridines potentiate synaptic and neuromuscular transmission by targeting the voltage-activated calcium channel beta subunit.

Authors: Zi-Zhen Wu; De-Pei Li; Shao-Rui Chen; Hui-Lin Pan
Journal: J Biol Chem Date: 2009-10-22 Impact factor: 5.157

Effects of 4-aminopyridine in myasthenia gravis.

1. The mode of action of 4-aminopyridine and guanidine on transmitter release from motor nerve terminals.

2. AN ELECTROPHYSIOLOGICAL INVESTIGATION OF NEUROMUSCULAR TRANSMISSION IN MYASTHENIA GRAVIS.

3. 4-aminopyridine--a new drug tested in the treatment of Eaton-Lambert syndrome.

4. Effects of 4-aminopyridine on transmission in excitatory and inhibitory synapses in the spinal cord.

5. Effects of 4-aminopyridine on neuromuscular transmission.

6. [Changes in transmitter release at frog neuromuscular junction induced by 4-aminopyridine].

7. Analysis of the effects of 4-amino pyridine on the lumbar cord of the cat. II. Modifications of certain spinal inhibitory phenomena, post-tetanic potentiation and dorsal root potentials.

8. Acetylcholine-induced channels and transmitter release at human endplates.

9. The effect of 4-aminopyridine on acetylcholine release.

10. Antagonism of the paralysis produced by botulinum toxin in the rat. The effects of tetraethylammonium, guanidine and 4-aminopyridine.

1. A review of 29 incidents involving 4-aminopyridine in non-target species reported to the ASPCA Animal Poison Control Center.

2. Potentiation of high voltage-activated calcium channels by 4-aminopyridine depends on subunit composition.

3. Lack of effect of 4-aminopyridine on choreic movements.

4. Eaton-Lambert syndrome: a clinical and electrophysiological study of a patient treated with 4-aminopyridine.

Review 5. Peripheral nerve injury and myelination: Potential therapeutic strategies.

6. Aligned microchannel polymer-nanotube composites for peripheral nerve regeneration: Small molecule drug delivery.

7. Treatment of walking impairment in multiple sclerosis with dalfampridine.

8. The effects of 4-aminopyridine and tetraethylammonium ions on normal and demyelinated mammalian nerve fibres.

9. Slowly inactivating potassium channels induced in Xenopus oocytes by messenger ribonucleic acid from Torpedo brain.

10. Aminopyridines potentiate synaptic and neuromuscular transmission by targeting the voltage-activated calcium channel beta subunit.