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Literature DB >> 4207527

Scrapie and transmissible mink encephalopathy: search for infectious nucleic acid.

R F Marsh, J S Semancik, K C Medappa, R P Hanson, R R Rueckert.

Abstract

Brain preparations from animals with scrapie or transmissible mink encephalopathy were phenol extracted and examined for the presence of pathogenic nucleic acid. Animals inoculated with various extracts remained healthy, and analysis on 2.6 to 5% polyacrylamide gels failed to detect a difference in extractable RNA species between infected and normal mink brain.

Entities: Chemical Disease Species

Mesh：

Substances：
Prions
RNA, Viral

Year: 1974 PMID： 4207527 PMCID： PMC355405

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

17 in total

1. An experimental examination of the scrapie agent in cell membrane mixtures. II. The association of scrapie activity with membrane fractions.

Authors: G C Millson; G D Hunter; R H Kimberlin
Journal: J Comp Pathol Date: 1971-04 Impact factor: 1.311

2. Further studies of the infectivity and stability of extracts and homogenates derived from scrapie affected mouse brains.

Authors: G D Hunter; R A Gibbons; R H Kimberlin; G C Millson
Journal: J Comp Pathol Date: 1969-01 Impact factor: 1.311

Review 3. Nature of the scrapie agent.

Authors: R A Gibbons; G D Hunter
Journal: Nature Date: 1967-09-02 Impact factor: 49.962

Scrapie and transmissible mink encephalopathy: search for infectious nucleic acid.

1. An experimental examination of the scrapie agent in cell membrane mixtures. II. The association of scrapie activity with membrane fractions.

2. Further studies of the infectivity and stability of extracts and homogenates derived from scrapie affected mouse brains.

Review 3. Nature of the scrapie agent.

4. Does the agent of scrapie replicate without nucleic acid?

5. The exceptionally small size of the scrapie agent.

6. The effect of beta-propiolactone on the scrapie agent.

7. Physical and chemical properties of the transmissible mink encephalopathy agent.

8. Electrophoretic separation of viral nucleic acids on polyacrylamide gels.

9. An experimental examination of the scrapie agent in cell membrane mixtures. 3. Studies of the operational size.

10. In situ breakage of turnip yellow mosaic virus RNA and in situ aggregation of the fragments.

1. Properties of the scrapie agent-endomembrane complex from hamster brain.

2. Molecular hybridization studies with scrapie brain nucleic acids. I. Search for specific DNA sequences.

3. Nature of the scrapie agent: evidence against a viroid.

4. Viroids and prions.