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Literature DB >> 4372389

Nature of the scrapie agent: evidence against a viroid.

Abstract

The postulated viroid nature of scrapie agent was tested. Since the agent could not be recovered after a carefully controlled phenol extraction of infected mouse brains, it is suggested that this agent is not a viroid.

Entities: Chemical Species

Mesh：

Substances：

Year: 1974 PMID： 4372389 PMCID： PMC355625

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

14 in total

1. Further studies of the infectivity and stability of extracts and homogenates derived from scrapie affected mouse brains.

Authors: G D Hunter; R A Gibbons; R H Kimberlin; G C Millson
Journal: J Comp Pathol Date: 1969-01 Impact factor: 1.311

Review 2. Nature of the scrapie agent.

Authors: R A Gibbons; G D Hunter
Journal: Nature Date: 1967-09-02 Impact factor: 49.962

3. Self-replication and scrapie.

Authors: J S Griffith
Journal: Nature Date: 1967-09-02 Impact factor: 49.962

4. Potato spindle tuber "virus". IV. A replicating, low molecular weight RNA.

Authors: T O Diener
Journal: Virology Date: 1971-08 Impact factor: 3.616

5. The exceptionally small size of the scrapie agent.

Authors: T Alper; D A Haig; M C Clarke
Journal: Biochem Biophys Res Commun Date: 1966-02-03 Impact factor: 3.575

6. Scrapie: a modified membrane hypothesis.

Authors: G D Hunter; R H Kimberlin; R A Gibbons
Journal: J Theor Biol Date: 1968-09 Impact factor: 2.691

7. Reconstitution of 50S ribosomal subunits from dissociated molecular components.

Authors: M Nomura; V A Erdmann
Journal: Nature Date: 1970-11-21 Impact factor: 49.962

8. Potato spindle tuber virus: a plant virus with properties of a free nucleic acid. II. Characterization and partial purification.

Authors: T O Diener; W B Raymer
Journal: Virology Date: 1969-03 Impact factor: 3.616

Nature of the scrapie agent: evidence against a viroid.

1. Further studies of the infectivity and stability of extracts and homogenates derived from scrapie affected mouse brains.

Review 2. Nature of the scrapie agent.

3. Self-replication and scrapie.

4. Potato spindle tuber "virus". IV. A replicating, low molecular weight RNA.

5. The exceptionally small size of the scrapie agent.

6. Scrapie: a modified membrane hypothesis.

7. Reconstitution of 50S ribosomal subunits from dissociated molecular components.

8. Potato spindle tuber virus: a plant virus with properties of a free nucleic acid. II. Characterization and partial purification.

9. Is the scrapie agent a viroid?

10. Potato spindle tuber virus: a plant virus with properties of a free nucleic acid.

1. Properties of the scrapie agent-endomembrane complex from hamster brain.

2. Inactivation of poliovirus in digested sludge.

3. Molecular hybridization studies with scrapie brain nucleic acids. I. Search for specific DNA sequences.

4. Viroids and prions.