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Literature DB >> 4201867

Cerebrovascular response to intracarotid injection of serotonin before and after middle cerebral artery occlusion.

Abstract

The effect of intracarotid injection of serotonin (5-HT) on internal carotid artery flow and oxygen availability (O(2)a) of the cerebral cortex was studied in 10 baboons. Vasoconstriction occurred in the vascular bed of the territory supplied by the injected artery. After one middle cerebral artery was occluded the vasoconstrictor effect of 5-HT was more pronounced, particularly in the non-ischaemic hemisphere. The capacity of the cerebral vessels to provide collateral blood flow was reduced in both ischaemic and non-ischaemic areas of brain. As a result of focal cerebral ischaemia, 5-HT may accumulate in the brain and contribute to the progression of infarction.

Entities: Chemical Disease Species

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Year: 1973 PMID： 4201867 PMCID： PMC494449 DOI： 10.1136/jnnp.36.5.724

Source DB: PubMed Journal: J Neurol Neurosurg Psychiatry ISSN： 0022-3050 Impact factor: 10.154

43 in total

1. Effect of 5-hydroxytryptophan on the cerebral electrical activity of the rabbit.

Authors: F R DOMER; V G LONGO
Journal: Arch Int Pharmacodyn Ther Date: 1962-03-01

2. The cerebral collateral circulation. II. Production of cerebral infarction by ischemic anoxia and its reversibility in early stages.

Authors: D DENNY-BROWN; J S MEYER
Journal: Neurology Date: 1957-08 Impact factor: 9.910

3. Localized changes in properties of the blood and effects of anticoagulant drugs in experimental cerebral infarction.

Authors: J S MEYER
Journal: N Engl J Med Date: 1958-01-23 Impact factor: 91.245

4. Some central actions of 5-hydroxytryptamine and various antagonists.

Authors: J H GADDUM; M VOGT
Journal: Br J Pharmacol Chemother Date: 1956-06

5. Estimation of levels of serotonin and 5-hydroxyindoles in whole blood by an autoanalytical procedure: observations on the blood-brain barrier.

Authors: K M Welch; J S Meyer; S Kwant
Journal: J Neurochem Date: 1972-04 Impact factor: 5.372

Cerebrovascular response to intracarotid injection of serotonin before and after middle cerebral artery occlusion.

1. Effect of 5-hydroxytryptophan on the cerebral electrical activity of the rabbit.

2. The cerebral collateral circulation. II. Production of cerebral infarction by ischemic anoxia and its reversibility in early stages.

3. Localized changes in properties of the blood and effects of anticoagulant drugs in experimental cerebral infarction.

4. Some central actions of 5-hydroxytryptamine and various antagonists.

5. Estimation of levels of serotonin and 5-hydroxyindoles in whole blood by an autoanalytical procedure: observations on the blood-brain barrier.

6. The response of cortical vessels to serotonin in experimental cerebral infarction.

7. Cerebral ischemia. II. The no-reflow phenomenon.

8. The effect of serotonin on cranial vessels and its significance in migraine.

9. Intracranial arterial spasm associated with craniocerebral trauma.

10. Diaschisis resulting from acute unilateral cerebral infarction. Quantitative evidence for man.

1. Enhanced vesicular transport of exogenous peroxidase across cerebral vessels, induced by serotonin.

2. Cerebral circulatory and metabolic effects of 5-hydroxytryptamine in anesthetized baboons.

3. Serotonin in contused spinal cord.

4. Plasma serotonin contents in cerebrovascular disease.

5. A follow-up study of platelet-rich plasma serotonin in clinical subtypes of cerebral infarction.

6. Influence of cerebral embolism on brain monoamines.