Literature DB >> 4186

Effect of SAS (a new 10-N-acylaminophenothiazine) on gastric secretion and ulceration in rats.

A Kumar, H L Sharma, V N Sharma.   

Abstract

The antiulcer and antisecretory activity of 2-chloro-10-[4'(N-beta-hydroxyethyl) piperazinyl-1'] acetylphenothiazine (SAS) has been investigated. At 10 and 20 mg/kg (s.c.) the drug was found to possess potent antigastric secretory and antiulcer activity (both in shay and stress ulcers) and did not exhibit any peripheral parasympathetic blocking activity. The pronounced antispasmodic activity of SAS was nonspecific rather than a specific parasympatholytic effect.

Entities:  

Mesh：

Substances：

Year:  1976        PMID： 4186      PMCID： PMC1666886          DOI： 10.1111/j.1476-5381.1976.tb07462.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  7 in total

1.  PHARMACOLOGICAL RESEARCH ON GEFARNATE, A NEW SYNTHETIC ISOPRENOID WITH AN ANTI-ULCER ACTION.

Authors:  E ADAMI; E MARAZZI-UBERTI; C TURBA
Journal:  Arch Int Pharmacodyn Ther       Date:  1964-01-01

2.  Clinical trials of 10-(alpha-dimethylaminopropionyl)-phenothiazine methobromide. A. The inhibitory effect on the gastric secretion by comparison with atropine sulphate, prantal and Ro 2-3773.

Authors:  J TOMENIUS
Journal:  Acta Med Scand       Date:  1957-03-10

3.  Inhibition of food-stimulated gastrin release by a topical anesthetic, oxethazaine.

Authors:  E L Posey; K Boler; L Posey
Journal:  Am J Dig Dis       Date:  1969-11

4.  Phenothiazines as local anesthetics.

Authors:  V N Sharma; R L Mital; S P Banerjee; H L Sharma
Journal:  J Med Chem       Date:  1971-01       Impact factor: 7.446

5.  Synthesis and pharmacological action of 3-amino-2,1-benzisothiazoles.

Authors:  R F Meyer; B L Cummings; P Bass; H O Collier
Journal:  J Med Chem       Date:  1965-07       Impact factor: 7.446

6.  Effect of aminoguanidine, chlorpromazine and NSD-1055 on gastric secretion and ulceration in the Shay rat.

Authors:  A G Radwan; G B West
Journal:  Br J Pharmacol       Date:  1971-01       Impact factor: 8.739

7.  Pharmacologic actions of ethyl-methyl-isooctenyl amine (EMOA), a new parasympathetic ganglionic blocking agent.

Authors:  E G PARDO; I MENDEZ; R VARGAS; J CATO; J LAGUNA
Journal:  J Pharmacol Exp Ther       Date:  1956-04       Impact factor: 4.030
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.