Literature DB >> 418546

Double controlled comparison of IDU and trifluorothymidine in thirty-three patients with superficial herpetic keratitis.

P R Laibson, J J Arentsen, W D Mazzanti, R A Eiferman.   

Abstract

Thirty-three patients were followed in a double controlled study to test the efficacy of IDU and TFT on superficial epithelial herpes simplex virus infection. Sixteen received TFT and 17, IDU. There were four failures in patients on IDU therapy and no failures in the 16 patients using TFT. These results indicate a trend for greater efficacy of TFT than IDU. In those patients who healed with IDU and with TFT, there was no difference in the number of days to heal in each group.

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Year:  1977        PMID: 418546      PMCID: PMC1311553     

Source DB:  PubMed          Journal:  Trans Am Ophthalmol Soc        ISSN: 0065-9533


  3 in total

1.  SYNTHESES OF 5-TRIFLUOROMETHYLURACIL AND 5-TRIFLUOROMETHYL-2'-DEOXYURIDINE.

Authors:  C HEIDELBERGER; D G PARSONS; D C REMY
Journal:  J Med Chem       Date:  1964-01       Impact factor: 7.446

2.  Clinical evaluation of trifluorothymidine in the treatment of herpes simplex corneal ulcers.

Authors:  P C Wellings; P N Awdry; F H Bors; B R Jones; D C Brown; H E Kaufman
Journal:  Am J Ophthalmol       Date:  1972-06       Impact factor: 5.258

3.  Newer compounds in therapy of herpes simplex keratitis.

Authors:  R A Hyndiuk; H E Kaufman
Journal:  Arch Ophthalmol       Date:  1967-11
  3 in total
  7 in total

Review 1.  Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis.

Authors:  Kirk R Wilhelmus
Journal:  Cochrane Database Syst Rev       Date:  2015-01-09

2.  The treatment of herpes simplex virus epithelial keratitis.

Authors:  K R Wilhelmus
Journal:  Trans Am Ophthalmol Soc       Date:  2000

Review 3.  Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis.

Authors:  Kirk R Wilhelmus
Journal:  Cochrane Database Syst Rev       Date:  2010-12-08

4.  Randomised trial of ganciclovir and acyclovir in the treatment of herpes simplex dendritic keratitis: a multicentre study.

Authors:  H B Hoh; C Hurley; C Claoue; M Viswalingham; D L Easty; P Goldschmidt; L M Collum
Journal:  Br J Ophthalmol       Date:  1996-02       Impact factor: 4.638

5.  Functional differences in nucleoside and nucleobase transporters expressed on the rabbit corneal epithelial cell line (SIRC) and isolated rabbit cornea.

Authors:  Soumyajit Majumdar; Giridhar S Tirucherai; Dhananjay Pal; Ashim K Mitra
Journal:  AAPS PharmSci       Date:  2003

Review 6.  Trifluridine: a review of its antiviral activity and therapeutic use in the topical treatment of viral eye infections.

Authors:  A A Carmine; R N Brogden; R C Heel; T M Speight; G S Avery
Journal:  Drugs       Date:  1982-05       Impact factor: 9.546

7.  Corneal epithelial dysplasia after trifluridine use.

Authors:  P C Maudgal; B Van Damme; L Missotten
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1983       Impact factor: 3.117

  7 in total

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