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Literature DB >> 14186018

SYNTHESES OF 5-TRIFLUOROMETHYLURACIL AND 5-TRIFLUOROMETHYL-2'-DEOXYURIDINE.

Abstract

Entities: Chemical

Keywords: ADENOCARCINOMA; ANTINEOPLASTIC AGENTS; CHEMISTRY, PHARMACEUTICAL; COLIPHAGES; DNA; DNA, VIRAL; EXPERIMENTAL LAB STUDY; MICE; NEOPLASMS, EXPERIMENTAL; NUCLEOSIDES; PHARMACOLOGY; URACIL

Mesh：

Substances：

Year: 1964 PMID： 14186018 DOI： 10.1021/jm00331a001

Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446

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27 in total

Review 1. TAS-102, a novel antitumor agent: a review of the mechanism of action.

Authors: Heinz-Josef Lenz; Sebastian Stintzing; Fotios Loupakis
Journal: Cancer Treat Rev Date: 2015-06-06 Impact factor: 12.111

2. Combined efficacy and mechanism of trifluridine and SN-38 in a 5-FU-resistant human colorectal cancer cell lines.

Authors: Kazuaki Matsuoka; Teiji Takechi
Journal: Am J Cancer Res Date: 2017-12-01 Impact factor: 6.166

3. HEp-2 cell- and herpes simplex virus type 1- induced deoxythymidine kinases: inhibition by derivatives of 5-trifluoromethyl-2'-deoxyuridine.

Authors: B L Wigdahl; J R Parkhurst
Journal: Antimicrob Agents Chemother Date: 1978-09 Impact factor: 5.191

4. Trifluorothymidine exhibits potent antitumor activity via the induction of DNA double-strand breaks.

Authors: Norihiko Suzuki; Fumio Nakagawa; Mamoru Nukatsuka; Masakazu Fukushima
Journal: Exp Ther Med Date: 2011-03-21 Impact factor: 2.447

5. Biological effects of 5-carboxy-2'-deoxyuridine: hydrolysis product of 5-trifluoromethyl-2'-deoxyuridine.

Authors: D W Clough; B L Wigdahl; J R Parkhurst
Journal: Antimicrob Agents Chemother Date: 1978-07 Impact factor: 5.191

6. Double controlled comparison of IDU and trifluorothymidine in thirty-three patients with superficial herpetic keratitis.

Authors: P R Laibson; J J Arentsen; W D Mazzanti; R A Eiferman
Journal: Trans Am Ophthalmol Soc Date: 1977

SYNTHESES OF 5-TRIFLUOROMETHYLURACIL AND 5-TRIFLUOROMETHYL-2'-DEOXYURIDINE.

Review 1. TAS-102, a novel antitumor agent: a review of the mechanism of action.

2. Combined efficacy and mechanism of trifluridine and SN-38 in a 5-FU-resistant human colorectal cancer cell lines.

3. HEp-2 cell- and herpes simplex virus type 1- induced deoxythymidine kinases: inhibition by derivatives of 5-trifluoromethyl-2'-deoxyuridine.

4. Trifluorothymidine exhibits potent antitumor activity via the induction of DNA double-strand breaks.

5. Biological effects of 5-carboxy-2'-deoxyuridine: hydrolysis product of 5-trifluoromethyl-2'-deoxyuridine.

6. Double controlled comparison of IDU and trifluorothymidine in thirty-three patients with superficial herpetic keratitis.

Review 7. TAS-102: a novel antimetabolite for the 21st century.

8. Experimental herpes simplex virus type 1 encephalitis: treatment with 5-trifluoromethyl-2'-deoxyuridine.

9. New active drugs for the treatment of advanced colorectal cancer.

10. Antitumor activity of FTC-092, a masked 5-trifluoromethyl-2'-deoxyuridine derivative.