Literature DB >> 4181523

A "Lepore" type of hybrid gamma-globulin.

H G Kunkel, J B Natvig, F G Joslin.   

Abstract

No explanation has been available concerning the gamma globulin defect in a unique family with one member whose serum was devoid of all the usual Gm genetic antigens. In the present study, it was found that this serum lacks ordinary gammaG1 and gammaG3 proteins and contains instead hybrid molecules of the type gammaG3-gammaG1. These were demonstrated most clearly by the precipitation of gammaG1 proteins with antisera specific for gammaG3 antigens. The analogy to the delta-beta chain hybrids, established for Lepore-type hemoglobins, was striking. An unequal homologous crossover involving mispairing of heavy chain cistrons would readily explain the deletion of genetic markers.

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Year:  1969        PMID： 4181523      PMCID： PMC285966          DOI： 10.1073/pnas.62.1.144

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  10 in total

1.  A GENETIC STUDY OF THE ANTIGENS ASSOCIATED WITH THE GM(B) FACTOR OF HUMAN GAMMA GLOBULIN.

Authors:  A G STEINBERG; R GOLDBLUM
Journal:  Am J Hum Genet       Date:  1965-03       Impact factor: 11.025

2.  The fusion of two peptide chains in hemoglobin Lepore and its interpretation as a genetic deletion.

Authors:  C BAGLIONI
Journal:  Proc Natl Acad Sci U S A       Date:  1962-11-15       Impact factor: 11.205

3.  The hydrolysis of rabbit y-globulin and antibodies with crystalline papain.

Authors:  R R PORTER
Journal:  Biochem J       Date:  1959-09       Impact factor: 3.857

4.  The C-terminal sequences of the heavy chains of human immunoglobulin G myeloma proteins of differing isotopes and allotypes.

Authors:  J W Prahl
Journal:  Biochem J       Date:  1967-12       Impact factor: 3.857

Review 5.  Genes and immunoglobulins.

Authors:  L Mårtensson
Journal:  Vox Sang       Date:  1966 Sep-Oct       Impact factor: 2.144

6.  Heterogeneity of anti-gamma-globulin factors detected by pepsin-digested human gamma G-globulin.

Authors:  J B Natvig
Journal:  Acta Pathol Microbiol Scand       Date:  1966

7.  Two unusual Gm alleles: their implications for the genetics of the Gm antigens.

Authors:  A G Steinberg; W A Muir; S A McIntire
Journal:  Am J Hum Genet       Date:  1968-05       Impact factor: 11.025

8.  H CHAIN SUBGROUPS OF MYELOMA PROTEINS AND NORMAL 7S GAMMA-GLOBULIN.

Authors:  H M GREY; H G KUNKEL
Journal:  J Exp Med       Date:  1964-08-01       Impact factor: 14.307

9.  Studies of the Vi (gamma-2c) subgroup of gamma-globulin. A relationship between concentration and genetic type among normal individuals.

Authors:  W J Yount; H G Kunkel; S D Litwin
Journal:  J Exp Med       Date:  1967-01-01       Impact factor: 14.307

10.  Immunoglobulin isoantigens (allotypes) in the mouse. II. Allotypic analysis of three gammaG2-myeloma proteins from (NZB x BALB/c)F1 hybrids and of normal gammaG2-globulins.

Authors:  N L Warner; L A Herzenberg; G Goldstein
Journal:  J Exp Med       Date:  1966-04-01       Impact factor: 14.307
  10 in total
  20 in total

1.  Evidence for "deleted" or "silent" genes homozygous at the locus coding for the constant region of the gamma3 chain.

Authors:  G Lefranc; L Rivat; C Rivat; J Loiselet; C Ropartz
Journal:  Am J Hum Genet       Date:  1976-01       Impact factor: 11.025

2.  Porcine IgG: structure, genetics, and evolution.

Authors:  J E Butler; Nancy Wertz; Nicholas Deschacht; Imre Kacskovics
Journal:  Immunogenetics       Date:  2008-12-02       Impact factor: 2.846

3.  Recombination, mutation, or constitutive expression at a Gm locus and familial hypergammaglobulinemia.

Authors:  G Lefranc; L Rivat; J P Salier; E van Loghem; H Aydenian; P Zalzal; L Chakhachiro; J Loiselet; C Ropartz
Journal:  Am J Hum Genet       Date:  1977-09       Impact factor: 11.025

4.  A pedigree demonstrating the transmission of a Gm2,8,21 phenogroup.

Authors:  A G Steinberg; A Muir; L Rivat; C Ropartz
Journal:  Am J Hum Genet       Date:  1970-07       Impact factor: 11.025

5.  Genetics of human immunoglobulins.

Authors:  J B Natvig
Journal:  Biochem J       Date:  1970-04       Impact factor: 3.857

Review 6.  Hybrid Ig molecules: implication for current theories on immunoglobulin synthesis and evolution.

Authors:  A C Wang; I Y Wang
Journal:  Surv Immunol Res       Date:  1983

7.  Hybrid gamma 2b-gamma 2a genes expressed in myeloma variants: evidence for homologous recombination.

Authors:  S A Tilley; L A Eckhardt; K B Marcu; B K Birshtein
Journal:  Proc Natl Acad Sci U S A       Date:  1983-11       Impact factor: 11.205

8.  Three monoclonal immunoglobulins, an IgG2(kappa), an IgM(kappa) and an IgM/A hybrid, in one patient. I. Isolation and characterization.

Authors:  E Tung; T K Kuan; G W Litman; A C Wang
Journal:  Immunology       Date:  1981-10       Impact factor: 7.397

9.  Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes.

Authors:  J Ellison; L Hood
Journal:  Proc Natl Acad Sci U S A       Date:  1982-03       Impact factor: 11.205

10.  Variants of a mouse myeloma cell line that synthesize immunoglobulin heavy chains having an altered serotype.

Authors:  J L Preud'Homme; B K Birshtein; M D Scharff
Journal:  Proc Natl Acad Sci U S A       Date:  1975-04       Impact factor: 11.205
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