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Literature DB >> 16742526

The C-terminal sequences of the heavy chains of human immunoglobulin G myeloma proteins of differing isotopes and allotypes.

Abstract

The sequences of the C-terminal octadecapeptides obtained by cyanogen bromide cleavage of the gamma-chains of myeloma proteins of the four subclasses, and a urinary heavy-chain-disease protein, have been determined. Although the sequences were markedly homologous, unique replacements were identified that distinguished between the gamma(2b), gamma(2c) and gamma(2d) subclasses. The data are in accord with the postulated existence of four genetic loci or cistrons, these having arisen by the process of gene duplication.

Entities: Chemical Disease Species

Year: 1967 PMID： 16742526 PMCID： PMC1198421 DOI： 10.1042/bj1051019

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

35 in total

1. Studies on papain produced subunits of human gamma-G-globulins. II. Structures of peptides related to the genetic Gm activity of gamma-G-globulin Fc-fragments.

Authors: N O Thorpe; H F Deutsch
Journal: Immunochemistry Date: 1966-07

Review 2. Genes and immunoglobulins.

Authors: L Mårtensson
Journal: Vox Sang Date: 1966 Sep-Oct Impact factor: 2.144

The C-terminal sequences of the heavy chains of human immunoglobulin G myeloma proteins of differing isotopes and allotypes.

1. Studies on papain produced subunits of human gamma-G-globulins. II. Structures of peptides related to the genetic Gm activity of gamma-G-globulin Fc-fragments.

Review 2. Genes and immunoglobulins.

3. Genetically determined antigen of the Ne subgroup of gamma-globulin: detection by precipitin analysis.

4. Relation between Gm(f) and the structure of the gamma-globulin molecule.

5. Gm(g)--a "new" gamma-globulin factor.

6. The N- and c-terminal amino acid sequences of the heavy chain from a pathological human immunoglobulin IgG.

7. Comparison of the C-terminal amino-acid sequence of two horse immunoglobulins IgG and IgG(T).

8. Studies on the catabolism of gamma- G subunits and chains.

9. GM and INV factors in subclasses of human IgG.

10. Structural studies of human gamma-G-myeloma proteins of different antigenic subgroups and genetic specificities.

1. Protein Hal: partial deletion of a " " immunoglobulin gene(s) and apparent reinitiation at an internal AUG codon.

2. Localization of Gm markers to different molecular regions of the Fc fragment.

3. A "Lepore" type of hybrid gamma-globulin.

4. Absence of disulfide bonds linking the heavy and light chains: a property of a genetic variant of gamma-A2 globulins.

5. Plasmocytoma proteins.

6. Allotype-related sequence variation of the heavy chain of rabbit immunoglobulin G.

7. Disulphide bridges of the heavy chain of human immunoglobulin G2.

8. Human immunoglobulin subclasses. Partial amino acid sequence of the constant region of a gamma 4 chain.

9. Variation in the N-terminal sequence of heavy chains of immunoglobulin G from rabbits of different allotype.

10. Metabolic properties of IgG subclasses in man.