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Literature DB >> 417917

Mutagenicity of the halogenated olefin, 2-bromo-2-chloro-1,1-difluoroethylene, a presumed metabolite of the inhalation anesthetic halothane.

Abstract

The presumed halothane metabolite, 2-bromo-1,1-difluoroethylene, produces both base substitution and frameshift mutations in Salmonella typhimurium. Direct mutagenesis of isolated DNA also was observed by using a Bacillus subtils transformation assay to score the production of mutagenic lesions in transforming DNA.

Entities: Chemical Species

Mesh：

Substances：

Year: 1977 PMID： 417917 PMCID： PMC1475352 DOI： 10.1289/ehp.772165

Source DB: PubMed Journal: Environ Health Perspect ISSN： 0091-6765 Impact factor: 9.031

21 in total

1. Induction of mutations in transforming DNA by hydroxylamine.

Authors: E FREESE; H B STRACK
Journal: Proc Natl Acad Sci U S A Date: 1962-10-15 Impact factor: 11.205

2. Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals.

Authors: J McCann; E Choi; E Yamasaki; B N Ames
Journal: Proc Natl Acad Sci U S A Date: 1975-12 Impact factor: 11.205

3. Vinyl chloride dependent mutagensis: effects of liver extracts and free radicals.

Authors: A J Garro; J B Guttenplan; P Milvy
Journal: Mutat Res Date: 1976-04 Impact factor: 2.433

4. Anaerobic release of fluoride from halothane. Relationship to the binding of halothane metabolites to hepatic cellular constituents.

Authors: R A Van Dyke; A J Gandolf
Journal: Drug Metab Dispos Date: 1976 Jan-Feb Impact factor: 3.922

8. Nature of the ethylenediaminetetraacetic acid requirement for transformation of Bacillus subtilis with single-stranded deoxyribonucleic acid.

Authors: M J Tevethia; M Mandel
Journal: J Bacteriol Date: 1970-03 Impact factor: 3.490

Mutagenicity of the halogenated olefin, 2-bromo-2-chloro-1,1-difluoroethylene, a presumed metabolite of the inhalation anesthetic halothane.

1. Induction of mutations in transforming DNA by hydroxylamine.

2. Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals.

3. Vinyl chloride dependent mutagensis: effects of liver extracts and free radicals.

4. Anaerobic release of fluoride from halothane. Relationship to the binding of halothane metabolites to hepatic cellular constituents.

5. Angiosarcoma of the liver in a vinyl-chloride worker.

6. Altered sporulation and respiratory patterns in mutants of Bacillus subtilis induced by acridine orange.

7. Human, rat and mouse liver-mediated mutagenicity of vinyl chloride in S. typhimurium strains.

8. Nature of the ethylenediaminetetraacetic acid requirement for transformation of Bacillus subtilis with single-stranded deoxyribonucleic acid.

9. Mutagen testing using TRP+ reversion in Escherichia coli.

10. Recent findings on the carcinogenicity of chlorinated olefins.

Review 1. Occupational exposure to volatile anaesthetics: epidemiology and approaches to reducing the problem.