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Literature DB >> 417379

Inhibition of pentylenetetrazol-induced convulsions in rats by prostaglandin E1: role of brain monoamines.

Abstract

Prostaglandin E1-(PGE1-) induced inhibition of pentylenetetrazol (PTZ) convulsions in rats were significantly antagonized after pretreatment with drugs known to reduce brain serotonin activity, but not by pharmacological agents that decrease brain catecholamine activity. PGF2alpha also significantly inhibited PGE1 action. The results suggest that PGE1-induced inhibition of PTZ convulsions is not a direct effect, but an indirect one mediated through increase in brain serotonin activity.

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Year: 1978 PMID： 417379 DOI： 10.1007/bf00431857

Source DB: PubMed Journal: Psychopharmacology (Berl) ISSN： 0033-3158 Impact factor: 4.530

11 in total

1. Prostaglandins: antinociceptive effect of prostaglandin E1 in the rat.

Authors: A K Sanyal; S K Bhattacharya; P R Keshary; D N Srivastava; P K Debnath
Journal: Clin Exp Pharmacol Physiol Date: 1977 May-Jun Impact factor: 2.557

Review 2. Prostaglandins and the central nervous system.

Authors: F Coceani
Journal: Arch Intern Med Date: 1974-01

3. Central monoamines and convulsine thresholds in mice and rats.

Authors: M Kilian; H H Frey
Journal: Neuropharmacology Date: 1973-07 Impact factor: 5.250

4. p-Chlorophenylalanine: a specific depletor of brain serotonin.

Authors: B K Koe; A Weissman
Journal: J Pharmacol Exp Ther Date: 1966-12 Impact factor: 4.030

5. Long-lasting selective depletion of brain serotonin by 5,6-dihydroxytryptamine.

Authors: H G Baumgarten; A Björklund; L Lachenmayer; A Nobin; U Stenevi
Journal: Acta Physiol Scand Suppl Date: 1971

6. Prostaglandins: effect of prostaglandin E1 on brain, stomach and intestinal serotonin in rat.

Authors: P K Debnath; S K Bhattacharya; A K Sanyal; M K Poddar; J J Ghosh
Journal: Biochem Pharmacol Date: 1978-01-01 Impact factor: 5.858

7. Inhibitors of endogenous catecholamine biosynthesis.

Authors: S Spector
Journal: Pharmacol Rev Date: 1966-03 Impact factor: 25.468

8. Potentiation of antinociceptive action of morphine by prostaglandin E1 in albino rats.

Authors: S K Bhattacharya; P K Reddy; P K Debnath; A K Sanyal
Journal: Clin Exp Pharmacol Physiol Date: 1975 Jul-Aug Impact factor: 2.557

9. Prostaglandin E1 causes sedation and increases 5-hydroxytryptamine turnover in rat brain.

Authors: D R Haubrich; J Perez-Cruet; W D Reid
Journal: Br J Pharmacol Date: 1973-05 Impact factor: 8.739

10. Role of 5-hydroxytryptamine in prostaglandin E1-induced potentiation of hexobarbitone hypnosis in albino rats.

Authors: S K Bhatacharya; S N Mukhopadhyay; P K Debnath; A K Sanyal
Journal: Experientia Date: 1976

4 in total

1. Effects of intracerebroventricular administration of prostaglandin D2 on behaviour, blood pressure and body temperature as compared to prostaglandins E2 and F2 alpha.

Authors: U Förstermann; R Heldt; G Hertting
Journal: Psychopharmacology (Berl) Date: 1983 Impact factor: 4.530