Literature DB >> 417364

Effects of medial raphe and raphe magnus lesions on the analgesic activity of morphine and methadone.

W T Chance, G M Krynock, J A Rosecrans.   

Abstract

The effects of lesions of the raphe nuclei on opiate-induced antinociception and brain serotonin (5-HT) levels were investigated. Lesions of the medial raphe nucleus effectively antagonized the analgesic effects of morphine, but not methadone, and lowered brain 5-HT. The decrement in analgesic activity of morphine was reversed by pretreatment with 5-hydroxytryptophan. Lesions of the raphe magnus, a descending 5-HT system, antagonized the analgesic potency of both morphine and methadone. These experiments indicate a differential effect of 5-HT manipulation on opiate-induced analgesia, suggesting a different mechanism of analgesic action for morphine and methadone.

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Year:  1978        PMID： 417364     DOI： 10.1007/bf00431838

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  19 in total

1.  Raphe neurons: depression of activity by L-5-hydroxytryptophan.

Authors:  M E Trulson; B L Jacobs
Journal:  Brain Res       Date:  1975-10-31       Impact factor: 3.252

2.  Morphine analgesia: blockade by raphe magnus lesions.

Authors:  H K Proudfit; E G Anderson
Journal:  Brain Res       Date:  1975-11-21       Impact factor: 3.252

3.  EVIDENCE FOR THE EXISTENCE OF MONOAMINE NEURONS IN THE CENTRAL NERVOUS SYSTEM. II. EXPERIMENTALLY INDUCED CHANGES IN THE INTRANEURONAL AMINE LEVELS OF BULBOSPINAL NEURON SYSTEMS.

Authors:  A DAHLSTROEM; K FUXE
Journal:  Acta Physiol Scand Suppl       Date:  1965

Review 4.  Central nervous system mechanisms of analgesia.

Authors:  David J Mayer; Donald D Price
Journal:  Pain       Date:  1976-12       Impact factor: 6.961

5.  Modification of morphine analgesia by drugs affecting adrenergic and tryptaminergic mechanisms.

Authors:  M R Fennessy; J R Lee
Journal:  J Pharm Pharmacol       Date:  1970-12       Impact factor: 3.765

6.  Differential behavioral and neurochemical effects following lesions of the dorsal or median raphe nuclei in rats.

Authors:  B L Jacobs; W D Wise; K M Taylor
Journal:  Brain Res       Date:  1974-10-25       Impact factor: 3.252

7.  Regional 5-hydroxytryptamine following selective midbrain raphe lesions in the rat.

Authors:  S A Lorens; H C Guldberg
Journal:  Brain Res       Date:  1974-09-20       Impact factor: 3.252

8.  Effects of intraventriculary injected 6-OH dopamine or midbrain raphe lesion on morphine analgesia in rats.

Authors:  R Samanin; S Bernasconi
Journal:  Psychopharmacologia       Date:  1972

9.  Antagonism of the analgesic effect of morphine and other drugs by p-chlorophenylalanine, a serotonin depletor.

Authors:  S S Tenen
Journal:  Psychopharmacologia       Date:  1968

10.  Effects of alpha-methyl-p-tyrosine, p-chlorophenylalanine, l-beta-(3,4-dihydroxyphenyl)alanine, 5-hydroxytryptophan and diethyldithiocarbamate on the analgesic activity of morphine and methylamphetamine in the mouse.

Authors:  C T Major; B J Pleuvry
Journal:  Br J Pharmacol       Date:  1971-08       Impact factor: 8.739
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  11 in total

1.  Sex differences in the anatomical and functional organization of the periaqueductal gray-rostral ventromedial medullary pathway in the rat: a potential circuit mediating the sexually dimorphic actions of morphine.

Authors:  Dayna R Loyd; Anne Z Murphy
Journal:  J Comp Neurol       Date:  2006-06-10       Impact factor: 3.215

2.  Entanglement between thermoregulation and nociception in the rat: the case of morphine.

Authors:  Nabil El Bitar; Bernard Pollin; Elias Karroum; Ivanne Pincedé; Daniel Le Bars
Journal:  J Neurophysiol       Date:  2016-09-07       Impact factor: 2.714

3.  Simultaneous multi- and single-unit recordings in the rostral ventromedial medulla of ketamine-anaesthetized rats, and the cross-correlogram analysis of their interactions.

Authors:  S McGaraughty; S Reinis
Journal:  Exp Brain Res       Date:  1993       Impact factor: 1.972

4.  Visualizing acute pain-morphine interaction in descending monoamine nuclei with Fos.

Authors:  Dusica Bajic; Kathryn G Commons
Journal:  Brain Res       Date:  2009-10-13       Impact factor: 3.252

5.  Involvement of 5-hydroxytryptamine in the analgesic action of pethidine and morphine in mice.

Authors:  R Botting; A Morinan
Journal:  Br J Pharmacol       Date:  1982-04       Impact factor: 8.739

6.  On the role of 5-hydroxytryptamine in drug-induced antinociception.

Authors:  M F Sugrue
Journal:  Br J Pharmacol       Date:  1979-04       Impact factor: 8.739

7.  Role of ascending and descending serotonergic pathways in the antinociceptive effect of baclofen.

Authors:  J Sawynok; A Reid
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-04       Impact factor: 3.000

8.  Morphine and supraspinal inhibition of spinal neurones: evidence that morphine decreases tonic descending inhibition in the anaesthetized cat.

Authors:  A W Duggan; B T Griersmith; R A North
Journal:  Br J Pharmacol       Date:  1980-07       Impact factor: 8.739

9.  Studies on the separate roles of forebrain and spinal serotonin in morphine analgesia.

Authors:  S Romandini; E Esposito; R Samanin
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-03       Impact factor: 3.000

10.  Studies of brain structures involved in diffuse noxious inhibitory controls in the rat: the rostral ventromedial medulla.

Authors:  D Bouhassira; Z Bing; D Le Bars
Journal:  J Physiol       Date:  1993-04       Impact factor: 5.182
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