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Literature DB >> 4157346

Single-dose daily gentamicin therapy in urinary tract infection.

Abstract

Patients with urinary tract infection were treated for 8 to 15 days with one daily intramuscular injection of 160 mg of gentamicin or 60 or 80 mg every 8 h. Ten of 11 patients treated with one injection daily were cured as compared with 8 of 10 patients treated with three injections daily. Urinary concentrations of gentamicin were 3.2 to 600 mug/ml in all 8-h collections in patients receiving one injection daily and were 22 to 440 mug/ml in all 8-h collections in patients receiving three injections daily. The group treated once daily demonstrated a significant but reversible increase in mean serum creatinine concentration and decrease in mean creatinine clearance during therapy as compared with no change in the group treated with three injections daily. Decreases in renal function were correlated with higher milligram per kilogram doses and higher 1-h serum concentrations.

Entities: Chemical Disease Species

Mesh：

Substances：
Gentamicins
Creatinine

Year: 1974 PMID： 4157346 PMCID： PMC444672 DOI： 10.1128/AAC.6.4.465

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

9 in total

1. THE LOCALIZATION AND TREATMENT OF URINARY TRACT INFECTIONS: THE ROLE OF BACTERICIDAL URINE LEVELS AS OPPOSED TO SERUM LEVELS.

Authors: T A STAMEY; D E GOVAN; J M PALMER
Journal: Medicine (Baltimore) Date: 1965-01 Impact factor: 1.889

2. Antibacterial action of "broad-spectrum" penicillins, cephalosporins and other antibiotics against Gram-negative bacilli isolated from bacteremic patients.

Authors: N H Steigbigel; C E McCall; C W Reed; M Finland
Journal: Ann N Y Acad Sci Date: 1967-09-27 Impact factor: 5.691

3. Pharmacology of cefazolin in patients with normal and abnormal renal function.

Authors: M E Levison; S P Levison; K Ries; D Kaye
Journal: J Infect Dis Date: 1973-10 Impact factor: 5.226

4. Gentamicin, a new aminoglycoside antibiotic: clinical and laboratory studies in urinary tract infection.

Authors: C E Cox
Journal: J Infect Dis Date: 1969 Apr-May Impact factor: 5.226

5. Renal insufficiency associated with gentamicin therapy.

Authors: J N Wilfert; J P Burke; H A Bloomer; C B Smith
Journal: J Infect Dis Date: 1971-12 Impact factor: 5.226

6. Antibiotic susceptibility testing by a standardized single disk method.

Authors: A W Bauer; W M Kirby; J C Sherris; M Turck
Journal: Am J Clin Pathol Date: 1966-04 Impact factor: 2.493

7. Pseudomonas bacteremia: pharmacologic and other bases for failure of treatment with gentamicin.

Authors: G G Jackson; L J Riff
Journal: J Infect Dis Date: 1971-12 Impact factor: 5.226

8. In vitro evaluation of tobramycin, a new aminoglycoside antibiotic.

Authors: M E Levison; R Knight; D Kaye
Journal: Antimicrob Agents Chemother Date: 1972-05 Impact factor: 5.191

9. In vitro evaluation of a new aminoglycoside derivative of kanamycin, a comparison with tobramycin and gentamycin.

Authors: K Ries; M E Levison; D Kaye
Journal: Antimicrob Agents Chemother Date: 1973-04 Impact factor: 5.191

9 in total

20 in total

Single-dose daily gentamicin therapy in urinary tract infection.

1. THE LOCALIZATION AND TREATMENT OF URINARY TRACT INFECTIONS: THE ROLE OF BACTERICIDAL URINE LEVELS AS OPPOSED TO SERUM LEVELS.

2. Antibacterial action of "broad-spectrum" penicillins, cephalosporins and other antibiotics against Gram-negative bacilli isolated from bacteremic patients.

3. Pharmacology of cefazolin in patients with normal and abnormal renal function.

4. Gentamicin, a new aminoglycoside antibiotic: clinical and laboratory studies in urinary tract infection.

5. Renal insufficiency associated with gentamicin therapy.

6. Antibiotic susceptibility testing by a standardized single disk method.

7. Pseudomonas bacteremia: pharmacologic and other bases for failure of treatment with gentamicin.

8. In vitro evaluation of tobramycin, a new aminoglycoside antibiotic.

9. In vitro evaluation of a new aminoglycoside derivative of kanamycin, a comparison with tobramycin and gentamycin.

1. Once-daily aminoglycoside dosing: A new look at an old drug.

2. Single-dose antibiotic treatment: a new approach to lower urinary tract infections in primary care.

3. Once-daily dosing of aminoglycosides.

4. Aminoglycosides for Treatment of Bacteremia Due to Carbapenem-Resistant Klebsiella pneumoniae.

Review 5. Use of aminoglycosides in elderly patients. Pharmacokinetic and clinical considerations.

6. Daily single-dose gentamicin therapy in experimental pyelonephritis.

Review 7. Once-daily aminoglycoside administration: new strategies for an old drug.

8. Novel model-based dosing guidelines for gentamicin and tobramycin in preterm and term neonates.

Review 9. Urinary tract infections in older women: a clinical review.

10. Treatment with a single daily dose of gentamicin in urinary tract infection in relation to the site of infection.