Literature DB >> 4157332

Cell culture studies on the antiviral activity of ether derivatives of 5-hydroxymethyldeoxyuridine.

J B Meldrum, V S Gupta, J R Saunders.   

Abstract

The antiviral activity of several ether derivatives of 5-hydroxymethyldeoxyuridine against the herpesvirus of infectious bovine rhinotracheitis was determined in monolayer cultures of secondary bovine fetal kidney cells. 5-Methoxy-methyldeoxyuridine (OCH(3)UdR) was found to be markedly inhibitory against this virus. Pretreatment of the cells with OCH(3)UdR, simultaneous addition of OCH(3)UdR with virus to the cells, and postinfection treatment with OCH(3)UdR were found to be effective in inhibiting virus-induced cytopathogenic effect. Against this virus, OCH(3)UdR was found to be as potent as 5-iododeoxyuridine and cytosine arabinoside. The alpha-anomer of OCH(3)UdR did not show antiviral activity. Preliminarly toxicity studies indicate that OCH(3)UdR has a very low acute toxicity.

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Year:  1974        PMID： 4157332      PMCID： PMC444658          DOI： 10.1128/AAC.6.4.393

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  THE POSSIBLE ROLE OF RECOMBINATION IN THE INFECTION OF COMPETENT BACILLUS SUBTILIS BY BACTERIOPHAGE DEOXYRIBONUCLEIC ACID.

Authors:  S OKUBO; B STRAUSS; M STODOLSKY
Journal:  Virology       Date:  1964-12       Impact factor: 3.616

2.  CELL CULTURE STUDIES ON ANTIVIRAL AGENTS. I. ACTION OF CYTOSINE ARABINOSIDE AND SOME COMPARISONS WITH 5-IODO-2-DEOXYURIDINE.

Authors:  D A BUTHALA
Journal:  Proc Soc Exp Biol Med       Date:  1964-01

3.  Cure of vaccinia infection by 5-iodo-2'-deoxyuridine.

Authors:  H E KAUFMAN; A B NESBURN; E D MALONEY
Journal:  Virology       Date:  1962-12       Impact factor: 3.616

4.  IDU therapy of herpes simplex.

Authors:  H E KAUFMAN; A B NESBURN; E D MALONEY
Journal:  Arch Ophthalmol       Date:  1962-05

5.  Clinical cure of herpes simplex keratitis by 5-iodo-2-deoxyuridine.

Authors:  H E KAUFMAN
Journal:  Proc Soc Exp Biol Med       Date:  1962-02

6.  Clinical studies with systemic administration of antimetabolites of pyrimidine nucleosides in viral infections.

Authors:  P Calabresi
Journal:  Ann N Y Acad Sci       Date:  1965-07-30       Impact factor: 5.691

7.  Potential mechanisms of action of antiviral agents.

Authors:  W H Prusoff; B Goz
Journal:  Fed Proc       Date:  1973-06

8.  A nonmutagenic thymidine analog with antiviral activity. 5-Ethyldeoxyuridine.

Authors:  M Swierkowski; D Shugar
Journal:  J Med Chem       Date:  1969-05       Impact factor: 7.446

Review 9.  Pharmacology of viruses.

Authors:  B Goz; W H Prusoff
Journal:  Annu Rev Pharmacol       Date:  1970       Impact factor: 13.820

10.  Immunobiological studies with the virostatics 5-ethyl-2'-deoxyuridine (EDU) and 1-allyl-3,5-diethyl-6-chlorouracil (ACIU).

Authors:  K K Gauri; G Malorny; W Schiff
Journal:  Chemotherapy       Date:  1969       Impact factor: 2.544
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  5 in total

1.  Comparison of the antiviral effects of 5-methoxymethyl-deoxyuridine with 5-iododeoxyuridine, cytosine arabinoside, and adenine arabinoside.

Authors:  L A Babiuk; B Meldrum; V S Gupta; B T Rouse
Journal:  Antimicrob Agents Chemother       Date:  1975-12       Impact factor: 5.191

2.  Detoxification of DNA hydroperoxide by glutathione transferases and the purification and characterization of glutathione transferases of the rat liver nucleus.

Authors:  K H Tan; D J Meyer; N Gillies; B Ketterer
Journal:  Biochem J       Date:  1988-09-15       Impact factor: 3.857

3.  Effect of anti-herpesvirus drugs on human and bovine lymphoid function in vitro.

Authors:  L A Babiuk; B T Rouse
Journal:  Infect Immun       Date:  1975-12       Impact factor: 3.441

4.  In vitro antiherpesviral activity of 5-alkyl derivatives of 1-beta-D-arabinofuranosyluracil.

Authors:  H Machida; S Sakata; A Kuninaka; H Yoshino; C Nakayama; M Saneyoshi
Journal:  Antimicrob Agents Chemother       Date:  1979-08       Impact factor: 5.191

5.  Antiherpesviral activity and inhibitory action on cell growth of 5-alkenyl derivatives of 1-beta D-arabinofuranosyluracil.

Authors:  H Machida; A Kuninaka; H Yoshino; K Ikeda; Y Mizuno
Journal:  Antimicrob Agents Chemother       Date:  1980-06       Impact factor: 5.191
  5 in total

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