Literature DB >> 4148001

Control of guanylate cyclase activity in the rod outer segment.

R G Pannbacker.   

Abstract

Mammalian photoreceptors contain a guanylate cyclase which has a high specific activity and is inhibited by exposure of the rod outer segment to light. Several minutes are required for this inhibition to take effect, indicating that it is not a step in visual excitation. The activity of the enzyme is sensitive to the concentration of calcium ion in the medium, suggesting that light-induced changes in calcium distribution in the photoreceptor could control guanylate cyclase activity.

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Year:  1973        PMID： 4148001     DOI： 10.1126/science.182.4117.1138

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  9 in total

1.  Light-activated hydrolysis of GTP and cyclic GMP in the rod outer segments.

Authors:  E Bignetti; A Cavaggioni; R T Sorbi
Journal:  J Physiol       Date:  1978-06       Impact factor: 5.182

2.  Intracellular biochemical manipulation of phototransduction in detached rod outer segments.

Authors:  W A Sather; P B Detwiler
Journal:  Proc Natl Acad Sci U S A       Date:  1987-12       Impact factor: 11.205

3.  Visual transduction in vertebrate photoreceptors. Light activation of guanylate cyclase.

Authors:  I M Pepe; I Panfoli; H E Hamm
Journal:  Cell Biophys       Date:  1989-04

4.  Protons block the dark current of isolated retinal rods.

Authors:  P Mueller; E N Pugh
Journal:  Proc Natl Acad Sci U S A       Date:  1983-04       Impact factor: 11.205

5.  Protons suppress the dark current of frog retinal rods.

Authors:  P A Liebman; P Mueller; E N Pugh
Journal:  J Physiol       Date:  1984-02       Impact factor: 5.182

Review 6.  A short history of cGMP, guanylyl cyclases, and cGMP-dependent protein kinases.

Authors:  Alexander Y Kots; Emil Martin; Iraida G Sharina; Ferid Murad
Journal:  Handb Exp Pharmacol       Date:  2009

7.  Light-sensitive swelling of isolated frog rod outer segments as an in vitro assay for visual transduction and dark adaptation.

Authors:  D Bownds; A E Brodie
Journal:  J Gen Physiol       Date:  1975-10       Impact factor: 4.086

8.  Retinal guanylyl cyclase activating protein 1 forms a functional dimer.

Authors:  Sunghyuk Lim; Graham Roseman; Igor Peshenko; Grace Manchala; Diana Cudia; Alexander M Dizhoor; Glenn Millhauser; James B Ames
Journal:  PLoS One       Date:  2018-03-07       Impact factor: 3.240

9.  Investigating the Ca2+-dependent and Ca2+-independent mechanisms for mammalian cone light adaptation.

Authors:  Frans Vinberg; Vladimir J Kefalov
Journal:  Sci Rep       Date:  2018-10-26       Impact factor: 4.379
  9 in total

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