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Literature DB >> 2472205

Visual transduction in vertebrate photoreceptors. Light activation of guanylate cyclase.

Abstract

Light activation of guanylate cyclase at different calcium concentrations was studied in the rod outer segments of the toad retina. The enzyme becomes sensitive to calcium ions after a flash of light, showing an enhancement of its activity when Ca2+ concentration is lowered from 10(-4) M to 10(-8) M. A possible pathway of guanylate cyclase activation by light was also investigated by means of the antibody 4A to transducin. When added in excess to transducin, the antibody inhibits light activation of phosphodiesterase as well as of cyclase, suggesting a possible coupling of the two enzymes.

Entities: Chemical

Mesh：

Substances：

Year: 1989 PMID： 2472205 DOI： 10.1007/BF02797130

Source DB: PubMed Journal: Cell Biophys ISSN： 0163-4992

17 in total

Review 1. Cyclic GMP cascade of vision.

Authors: L Stryer
Journal: Annu Rev Neurosci Date: 1986 Impact factor: 12.449

2. Induction by cyclic GMP of cationic conductance in plasma membrane of retinal rod outer segment.

Authors: E E Fesenko; S S Kolesnikov; A L Lyubarsky
Journal: Nature Date: 1985 Jan 24-30 Impact factor: 49.962

3. Topographic analysis of antigenic determinants recognized by monoclonal antibodies to the photoreceptor guanyl nucleotide-binding protein, transducin.

Authors: D Deretic; H E Hamm
Journal: J Biol Chem Date: 1987-08-05 Impact factor: 5.157

Review 4. Visual transduction in vertebrate rods and cones: a tale of two transmitters, calcium and cyclic GMP.

Authors: E N Pugh; W H Cobbs
Journal: Vision Res Date: 1986 Impact factor: 1.886

5. Light-induced decreases in cGMP concentration precede changes in membrane permeability in frog rod photoreceptors.

Authors: R H Cote; M S Biernbaum; G D Nicol; M D Bownds
Journal: J Biol Chem Date: 1984-08-10 Impact factor: 5.157

6. Localization and assay of guanylate cyclase.

Authors: D Fleischman
Journal: Methods Enzymol Date: 1982 Impact factor: 1.600

7. Effect of light and calcium on cyclic GMP synthesis in rod outer segments of toad retina.

Authors: I M Pepe; A Boero; L Vergani; I Panfoli; C Cugnoli
Journal: Biochim Biophys Acta Date: 1986-12-19

8. The chemistry of vision.

Authors: D F O'Brien
Journal: Science Date: 1982-12-03 Impact factor: 47.728

9. Control of guanylate cyclase activity in the rod outer segment.

Authors: R G Pannbacker
Journal: Science Date: 1973-12-14 Impact factor: 47.728

10. Amplitude, kinetics, and reversibility of a light-induced decrease in guanosine 3',5'-cyclic monophosphate in frog photoreceptor membranes.

Authors: M L Woodruff; M D Bownds
Journal: J Gen Physiol Date: 1979-05 Impact factor: 4.086

2 in total

Review 1. Involvement of rhodopsin and ATP in the activation of membranous guanylate cyclase in retinal photoreceptor outer segments (ROS-GC) by GC-activating proteins (GCAPs): a new model for ROS-GC activation and its link to retinal diseases.

Authors: Vladimir A Bondarenko; Fumio Hayashi; Jiro Usukura; Akio Yamazaki
Journal: Mol Cell Biochem Date: 2009-11-26 Impact factor: 3.396

2. Regulation of bovine rod outer segment membrane guanylate cyclase by ATP, phosphodiesterase and metal ions.

Authors: A Sitaramayya; T Duda; R K Sharma
Journal: Mol Cell Biochem Date: 1995-07-19 Impact factor: 3.396

2 in total