Literature DB >> 4127631

Inhibition of deoxyribonucleic acid synthesis and bud formation by nalidixic acid in Hyphomicrobium neptunium.

R M Weiner, M A Blackman.   

Abstract

The relationship between chromosome replication and morphogenesis in the budding bacterium Hyphomicrobium neptunium has been investigated. Nalidixic acid was found to completely inhibit deoxyribonucleic acid synthesis, but not ribonucleic acid synthesis. The antibiotic was bacteriostatic to the organism for the initial 5 h of exposure; thereafter it was bacteriocidal. Observation of inhibited cultures revealed cells that had produced abnormally long stalks, but no buds. These results indicate that bud formation is coupled to chromosome replication in H. neptunium. They do not exclude the possibilities that cross wall formation and bud separation may also be coupled to chromosome replication.

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Year:  1973        PMID： 4127631      PMCID： PMC246499          DOI： 10.1128/jb.116.3.1398-1404.1973

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  15 in total

1.  Cell division during inhibition of deoxyribonucleic acid synthesis in Escherichia coli.

Authors:  C E Helmstetter; O Pierucci
Journal:  J Bacteriol       Date:  1968-05       Impact factor: 3.490

2.  Chromosome replication during development in Caulobacter crescentus.

Authors:  S T Degnen; A Newton
Journal:  J Mol Biol       Date:  1972-03-14       Impact factor: 5.469

3.  The regulation of DNA replication and cell division in E. coli B-r.

Authors:  D J Clark
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1968

4.  Independence of cell division and DNA replication in Bacillus subtilis.

Authors:  W D Donachie; D T Martin; K J Begg
Journal:  Nat New Biol       Date:  1971-06-30

5.  Specific loss of newly replicated deoxyribonucleic acid in nalidixic acid-treated Bacillus subtilis 168.

Authors:  G Ramareddy; H Reiter
Journal:  J Bacteriol       Date:  1969-11       Impact factor: 3.490

6.  Regulation of deoxyribonucleic acid replication and cell division in Escherichia coli B-r.

Authors:  D J Clark
Journal:  J Bacteriol       Date:  1968-10       Impact factor: 3.490

7.  Bactericidal action of nalidixic acid on Bacillus subtilis.

Authors:  T M Cook; K G Brown; J V Boyle; W A Goss
Journal:  J Bacteriol       Date:  1966-11       Impact factor: 3.490

8.  Timing of enzyme synthesis during outgrowth of spores of Bacillus cereus. II. Relationship between ordered enzyme synthesis and deoxyribonucleic acid replication.

Authors:  W Steinberg; H O Halvorson
Journal:  J Bacteriol       Date:  1968-02       Impact factor: 3.490

9.  Dependence of cell division on the completion of chromosome replication in Caulobacter.

Authors:  S T Degnen; A Newton
Journal:  J Bacteriol       Date:  1972-06       Impact factor: 3.490

10.  Deoxyribonucleic acid synthesis during microcyst germination in Myxococcus xanthus.

Authors:  D Zusman; E Rosenberg
Journal:  J Bacteriol       Date:  1968-10       Impact factor: 3.490
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  8 in total

1.  Development of Defined, Minimal, and Complete Media for the Growth of Hyphomicrobium neptunium.

Authors:  J A Havenner; B A McCardell; R M Weiner
Journal:  Appl Environ Microbiol       Date:  1979-07       Impact factor: 4.792

2.  Fine-structure evidence for cell membrane partitioning of the nucleoid and cytoplasm during bud formation in Hyphomonas species.

Authors:  P M Zerfas; M Kessel; E J Quintero; R M Weiner
Journal:  J Bacteriol       Date:  1997-01       Impact factor: 3.490

3.  Major outer membrane proteins unique to reproductive cells of Hyphomonas jannaschiana.

Authors:  N Shen; L Dagasan; D Sledjeski; R M Weiner
Journal:  J Bacteriol       Date:  1989-04       Impact factor: 3.490

4.  Timing of swarmer cell cycle morphogenesis and macromolecular synthesis by Hyphomicrobium neptunium in synchronous culture.

Authors:  T M Wali; G R Hudson; D A Danald; R M Weiner
Journal:  J Bacteriol       Date:  1980-10       Impact factor: 3.490

5.  Comparative genomic evidence for a close relationship between the dimorphic prosthecate bacteria Hyphomonas neptunium and Caulobacter crescentus.

Authors:  Jonathan H Badger; Timothy R Hoover; Yves V Brun; Ronald M Weiner; Michael T Laub; Gladys Alexandre; Jan Mrázek; Qinghu Ren; Ian T Paulsen; Karen E Nelson; Hoda M Khouri; Diana Radune; Julia Sosa; Robert J Dodson; Steven A Sullivan; M J Rosovitz; Ramana Madupu; Lauren M Brinkac; A Scott Durkin; Sean C Daugherty; Sagar P Kothari; Michelle Gwinn Giglio; Liwei Zhou; Daniel H Haft; Jeremy D Selengut; Tanja M Davidsen; Qi Yang; Nikhat Zafar; Naomi L Ward
Journal:  J Bacteriol       Date:  2006-10       Impact factor: 3.490

6.  Effect of cis-platinum(II)diamminodichloride on cell division of Hyphomicrobium and Caulobacter.

Authors:  R L Moore; R R Brubaker
Journal:  J Bacteriol       Date:  1976-01       Impact factor: 3.490

7.  Generation of buds, swellings, and branches instead of filaments after blocking the cell cycle of Rhizobium meliloti.

Authors:  J N Latch; W Margolin
Journal:  J Bacteriol       Date:  1997-04       Impact factor: 3.490

8.  Trimethoprim enhances the antibacterial activity of nalidixic and oxolinic acids and delays the emergence of resistance.

Authors:  A Bertolini; M Castelli; S Genedani; M Garuti
Journal:  Experientia       Date:  1980-02-15
  8 in total

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