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Literature DB >> 4982198

Specific loss of newly replicated deoxyribonucleic acid in nalidixic acid-treated Bacillus subtilis 168.

Abstract

Bacillus subtilis 168 thyA, thyB cells degrade and lose from 20 to 30% of their deoxyribonucleic acid (DNA) in 3.5 hr of exposure to 20 mug of nalidixic acid per ml. Degradation appears to be initiated at the replication point and to proceed sequentially along the chromosome from the most recently synthesized DNA to "older" DNA. Both DNA strands appear to be degraded equally, and essentially all of the products of degradation are soluble in cold acid.

Entities: Chemical Species

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Year: 1969 PMID： 4982198 PMCID： PMC250150 DOI： 10.1128/jb.100.2.724-729.1969

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

11 in total

1. The induction of thymine synthesis by T2 infection of a thymine requiring mutant of Escherichia coli.

Authors: H D BARNER; S S COHEN
Journal: J Bacteriol Date: 1954-07 Impact factor: 3.490

2. REQUIREMENTS FOR TRANSFORMATION IN BACILLUS SUBTILIS.

Authors: C Anagnostopoulos; J Spizizen
Journal: J Bacteriol Date: 1961-05 Impact factor: 3.490

3. The provocation of an early step of induction by thymine deprivation.

Authors: N E MELECHEN; P D SKAAR
Journal: Virology Date: 1962-01 Impact factor: 3.616

4. [Induction of the production of bacteriophages in lysogenic bacteria].

Authors: A LWOFF; L SIMINOVITCH; N KJELDGAARD
Journal: Ann Inst Pasteur (Paris) Date: 1950-12

5. On the mechanism of thymineless death in Bacillus subtilis.

Authors: R Rolfe
Journal: Proc Natl Acad Sci U S A Date: 1967-01 Impact factor: 11.205

6. Studies on the in vitro synthesis of transforming DNA.

Authors: A T Ganesan
Journal: Proc Natl Acad Sci U S A Date: 1968-11 Impact factor: 11.205

7. Replication of Bacillus subtilis DNA during germination in 5 bromouracil containing medium and marker mapping.

Authors: P C Huang; H Eberle; L B Boice; W R Romig
Journal: Genetics Date: 1968-12 Impact factor: 4.562

8. Bactericidal action of nalidixic acid on Bacillus subtilis.

Authors: T M Cook; K G Brown; J V Boyle; W A Goss
Journal: J Bacteriol Date: 1966-11 Impact factor: 3.490

9. Mechanism of action of nalidixic acid on Escherichia coli. Vi. Cell-free studies.

Authors: J V Boyle; T M Cook; W A Goss
Journal: J Bacteriol Date: 1969-01 Impact factor: 3.490

10. MECHANISM OF ACTION OF NALIDIXIC ACID ON ESCHERICHIA COLI.II. INHIBITION OF DEOXYRIBONUCLEIC ACID SYNTHESIS.

Authors: W A GOSS; W H DEITZ; T M COOK
Journal: J Bacteriol Date: 1965-04 Impact factor: 3.490

17 in total

1. Temporal sequence of events during the initiation process in Escherichia coli deoxyribonucleic acid replication: roles of the dnaA and dnaC gene products and ribonucleic acid polymerase.

Authors: J W Zyskind; L T Deen; D W Smith
Journal: J Bacteriol Date: 1977-03 Impact factor: 3.490

Specific loss of newly replicated deoxyribonucleic acid in nalidixic acid-treated Bacillus subtilis 168.

1. The induction of thymine synthesis by T2 infection of a thymine requiring mutant of Escherichia coli.

2. REQUIREMENTS FOR TRANSFORMATION IN BACILLUS SUBTILIS.

3. The provocation of an early step of induction by thymine deprivation.

4. [Induction of the production of bacteriophages in lysogenic bacteria].

5. On the mechanism of thymineless death in Bacillus subtilis.

6. Studies on the in vitro synthesis of transforming DNA.

7. Replication of Bacillus subtilis DNA during germination in 5 bromouracil containing medium and marker mapping.

8. Bactericidal action of nalidixic acid on Bacillus subtilis.

9. Mechanism of action of nalidixic acid on Escherichia coli. Vi. Cell-free studies.

10. MECHANISM OF ACTION OF NALIDIXIC ACID ON ESCHERICHIA COLI.II. INHIBITION OF DEOXYRIBONUCLEIC ACID SYNTHESIS.

1. Temporal sequence of events during the initiation process in Escherichia coli deoxyribonucleic acid replication: roles of the dnaA and dnaC gene products and ribonucleic acid polymerase.

2. Nalidixic acid for enrichment of auxotrophs in cultures of Salmonella typhimurium.

3. Conjugal deoxyribonucleic acid replication by Escherichia coli K-12: effect of nalidixic acid.

4. Deoxyribonucleic acid degradation and the lethal effect by myxin in Escherichia coli.

5. The fate of newly made DNA in Escherichia coli mutants thermosensitive in DNA synthesis.

6. Mechanism of action of nalidixic acid on conjugating bacteria.

7. Nalidixic acid: an antibacterial paradox.

8. Isolation and characterization of an Escherichia coli strain exhibiting partial tolerance to quinolones.

9. Nalidixic acid and macromolecular metabolism in Tetrahymena pyriformis: effects on protein synthesis.

10. Degradation of Escherichia coli DNA: evidence for limitation in vivo by protein X, the recA gene product.