Literature DB >> 412214

The antagonizing effect of aspartic acid on the brain levels of monoamines and free amino acids during the development of tolerance to the physical dependence on morphine.

H Koyuncuoğlu, E Genc, M Güngör, L Eroğlu, H Sağduyu.   

Abstract

Since it has been shown in previous study that aspartic acid prevents the development of physical dependence on and tolerance to morphine and antagonizes the abstinence syndrom signs, the biochemical bases of that prevention were investigated in the present study. The brain contents of serotonin, DA, NA, and free amino acids of the rats given aspartic acid and morphine separately and in combination were determined. It has been observed that most of the morphine-induced changes in the brain were normalized in the group given aspartic acid and morphine together. The relative ineffectiveness of aspartic acid in normalizing some amino acid levels decreased by morphine was discussed and some logical explanations were found.

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Year:  1977        PMID： 412214     DOI： 10.1007/bf00426778

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  34 in total

1.  Hypothesis: glutamic acid in migraine.

Authors:  M A Pollack; J H French
Journal:  Headache       Date:  1975-07       Impact factor: 5.887

2.  A SENSITIVE METHOD FOR SPECTROPHOTOFLUOROMETRIC ASSAY OF CATECHOLAMINES.

Authors:  C C CHANG
Journal:  Int J Neuropharmacol       Date:  1964-12

3.  The effect of p-chlorophenylalanine on opiate-induced running, analgesia, tolerance and physical dependence in mice.

Authors:  D L Cheney; A Goldstein
Journal:  J Pharmacol Exp Ther       Date:  1971-04       Impact factor: 4.030

4.  Role of catecholaminergic mechanisms in the expression of the morphine abstinence syndrome in rats.

Authors:  A Herz; J Bläsig; R Papeschi
Journal:  Psychopharmacologia       Date:  1974

5.  The role of dopamine and norepinephrine in the naloxone-induced abstinence of morphine-dependent mice.

Authors:  Y Maruyama; A E Takemori
Journal:  J Pharmacol Exp Ther       Date:  1973-06       Impact factor: 4.030

6.  The antagonistic effects of aspartic acid on some effects of morphine on rats.

Authors:  H Koyuncuoğlu; M Güngör; H Sağduyu; L Eroğlu
Journal:  Eur J Pharmacol       Date:  1974-06       Impact factor: 4.432

7.  Biogenic amines and narcotic effects. II. Serotonin turnover in the rat after acute and chronic morphine administration.

Authors:  G G Yarbrough; D M Buxbaum; E Sanders-Bush
Journal:  J Pharmacol Exp Ther       Date:  1973-05       Impact factor: 4.030

8.  Dissociation of morphine tolerance and dependence from brain serotonin synthesis rate in mice.

Authors:  P J Schechter; W Lovenberg; A Sjoerdsma
Journal:  Biochem Pharmacol       Date:  1972-03-01       Impact factor: 5.858

9.  The uptake of amino acids by particulate fractions from brain.

Authors:  S Navon; A Lajtha
Journal:  Biochim Biophys Acta       Date:  1969-04

10.  Effects of alpha-methyl-p-tyrosine, p-chlorophenylalanine, l-beta-(3,4-dihydroxyphenyl)alanine, 5-hydroxytryptophan and diethyldithiocarbamate on the analgesic activity of morphine and methylamphetamine in the mouse.

Authors:  C T Major; B J Pleuvry
Journal:  Br J Pharmacol       Date:  1971-08       Impact factor: 8.739
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  3 in total

1.  Effects of continuous and acute administration of small doses of apomorphine, alone or in combination with chlorpromazine, on the brain monoamines and free amino acid levels in the rat.

Authors:  H Koyuncuoğlu; S Atamer-Simşek; M Keyer-Uysal
Journal:  Psychopharmacology (Berl)       Date:  1979-11       Impact factor: 4.530

2.  The antagonizing effect of aspartic acid on morphine withdrawal and levallorphan-precipitated abstinence syndrome signs and on associated changes in brain levels of free amino acids in the rat.

Authors:  H Koyuncuoğlu; M Güngör; L Eroğlu; H Sağduyu
Journal:  Psychopharmacology (Berl)       Date:  1979-03-29       Impact factor: 4.530

3.  The inhibition by morphine and D-aspartic acid of antibody production against Salmonella typhimurium antigen in rats: its antagonism by L-aspartic acid.

Authors:  H Koyuncouğlu; O Anğ; D Inanç; H Sağduyu; M Güngör
Journal:  Agents Actions       Date:  1987-02
  3 in total

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