Literature DB >> 4119791

Radioimmunoassay for human alpha 1 -fetoprotein.

H K Silver, P Gold, S Feder, S O Freedman, J Shuster.   

Abstract

A method of radioimmunoassay has been developed for the quantitation of alpha(1)-fetoprotein in human serum. The assay requires 20 mul of serum, can be completed in 8 hr, and can reproducibly detect concentrations of 20 ng of alpha(1)-fetoprotein per ml of serum. Hence, the method is about 500-fold more sensitive for the detection of alpha(1)-fetoprotein than the Ouchterlony teohnique currently in general use. The procedure is of potential clinical value as an aid in the diagnosis of cancer and a number of noncancerous hepatic diseases.

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Year:  1973        PMID： 4119791      PMCID： PMC433297          DOI： 10.1073/pnas.70.2.526

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  9 in total

1.  Production of embryonal alpha-globulin by transplantable mouse hepatomas.

Authors:  G I ABELEV; S D PEROVA; N I KHRAMKOVA; Z A POSTNIKOVA; I S IRLIN
Journal:  Transplantation       Date:  1963-04       Impact factor: 4.939

2.  THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.

Authors:  F C GREENWOOD; W M HUNTER; J S GLOVER
Journal:  Biochem J       Date:  1963-10       Impact factor: 3.857

3.  -Foetoprotein in normal human serum.

Authors:  E Ruoslahti; M Seppälä
Journal:  Nature       Date:  1972-01-21       Impact factor: 49.962

4.  Effect of therapy on the serum level of alpha-1 fetoprotein in embryonal cell carcinoma.

Authors:  K Kithier; J Lusher; J Brought; M D Poulik
Journal:  J Pediatr       Date:  1972-07       Impact factor: 4.406

Review 5.  Alpha-fetoprotein in ontogenesis and its association with malignant tumors.

Authors:  G I Abelev
Journal:  Adv Cancer Res       Date:  1971       Impact factor: 6.242

6.  Production of embryonal serum alpha-globulin by hepatomas: review of experimental and clinical data.

Authors:  G I Abelev
Journal:  Cancer Res       Date:  1968-07       Impact factor: 12.701

7.  [Content of the embryo-specific alpha-globulin in the serum of the fetus, newborn infant and adult man with primary liver cancer].

Authors:  Iu S Tatarinov
Journal:  Vopr Med Khim       Date:  1965 Mar-Apr

8.  The radioimmunoassay of circulating carcinoembryonic antigen of the human digestive system.

Authors:  D M Thomson; J Krupey; S O Freedman; P Gold
Journal:  Proc Natl Acad Sci U S A       Date:  1969-09       Impact factor: 11.205

9.  Isolation and characterization of a human fetal-alpha-globulin from the sera of fetuses and a hepatoma patient.

Authors:  S Nishi
Journal:  Cancer Res       Date:  1970-10       Impact factor: 12.701
  9 in total
  6 in total

1.  Alpha-1-fetoprotein and alcoholic hepatitis.

Authors:  H Meshkinpour; H T Wepsic; W R Schmalhorst
Journal:  Am J Dig Dis       Date:  1974-08

2.  Markers of bile duct tumors.

Authors:  Giulia Malaguarnera; Maria Giordano; Isabella Paladina; Alessandra Rando; Mario Uccello; Francesco Basile; Antonio Biondi; Santo Carnazzo; Innocenza Alessandria; Clorinda Mazzarino
Journal:  World J Gastrointest Oncol       Date:  2011-04-15

3.  Carcinoembryonic antigen and alpha 1-fetoprotein in ulcerative colitis and regional enteritis.

Authors:  W G Thompson; R R Gillies; H K Silver; J Shuster; S O Freedman; P Gold
Journal:  Can Med Assoc J       Date:  1974-04-06       Impact factor: 8.262

4.  Radioimmunoassay of alpha-fetoprotein in human serum: clinical value in patients with liver diseases.

Authors:  J A Chayvialle; C Touillon; C Crozier; R Lambert
Journal:  Am J Dig Dis       Date:  1974-12

5.  Germ cell tumors of the testes.

Authors:  G D Braunstein
Journal:  West J Med       Date:  1977-05

6.  Relationship of total serum sialic acid to sialylglycoprotein acute-phase reactants in malignant melanoma.

Authors:  H K Silver; K A Karim; F A Salinas
Journal:  Br J Cancer       Date:  1980-05       Impact factor: 7.640
  6 in total

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