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Literature DB >> 4118294

Polycistronic effects of catabolite repression on the lac operon.

Abstract

The catabolite repression caused by glucose and glucose-6-phosphate has been studied for both beta-galactosidase and thiogalactoside transacetylase, the products of the operator proximal and distal cistrons of the lac operon, respectively. We find that both cistrons are affected coordinately by this form of repression. We also find that a single alteration at the lac promoter region is sufficient to abolish sensitivity to repression of both cistrons. From this, we conclude that there is only one target site for catabolite repression in the lac operon.

Entities: Chemical Gene

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Year: 1972 PMID： 4118294 PMCID： PMC251547 DOI： 10.1128/jb.112.3.1184-1192.1972

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

25 in total

1. THE RELATION OF CATABOLITE REPRESSION TO THE INDUCTION SYSTEM FOR BETA-GALACTOSIDASE IN ESCHERICHIA COLI.

Authors: W F LOOMIS; B MAGASANIK
Journal: J Mol Biol Date: 1964-03 Impact factor: 5.469

2. Fusions of the lac and trp Regions of the Escherichia coli Chromosome.

Authors: J H Miller; W S Reznikoff; A E Silverstone; K Ippen; E R Signer; J R Beckwith
Journal: J Bacteriol Date: 1970-12 Impact factor: 3.490

3. The step sensitive to catabolite repression and its reversal by 3'-5' cyclic AMP during induced synthesis of beta-galactosidase in E. coli.

Authors: M Jacquet; A Kepes
Journal: Biochem Biophys Res Commun Date: 1969-07-07 Impact factor: 3.575

Polycistronic effects of catabolite repression on the lac operon.

1. THE RELATION OF CATABOLITE REPRESSION TO THE INDUCTION SYSTEM FOR BETA-GALACTOSIDASE IN ESCHERICHIA COLI.

2. Fusions of the lac and trp Regions of the Escherichia coli Chromosome.

3. The step sensitive to catabolite repression and its reversal by 3'-5' cyclic AMP during induced synthesis of beta-galactosidase in E. coli.

4. Molecular basis of transient repression of beta-galactosidase in Escherichia coli.

5. Catabolite sensitive site of the lac operon.

6. Mechanism of beta-galactosidase induction in Escherichia coli.

7. Carabolite repression of the lac operon. Repression of translation.

8. Interaction of prophages at the att80 site with the chromosome of Escherichia coli.

9. Catabolite repression in Escherichia coli. A study of two hypotheses.

10. Operon coordination in different bacterial hosts.

1. Transient repression of catabolite-sensitive enzyme synthesis elicited by 2,4-dinitrophenol.

2. Inhibition of lacZ gene translation initiation in trp-lac fusion strains.

3. Catabolite translational effects on the lac messenger RNA of Escherichia coli K12.

4. Mutations in the L-arabinose operon of Escherichia coli B-r that result in hypersensitivity to catabolite repression.