Literature DB >> 4113485

Specific inhibition of plaque formation to phosphorylcholine by antibody against antibody.

H Cosenza, H Köhler.   

Abstract

Spleen cells from BALB/c mice immunized with heat-killed rough pneumococci (strain R36A) or spleen cells from normal mice immunized in vitro with the same antigen produce direct hemolytic plaques against sheep erythrocytes coated with pneumococcal C polysaccharide or conjugated with phosphorylcholine. Formation of plaques is specifically inhibited by phosphorylcholine or by antiserum to mouse immunoglobulin A myeloma protein which binds phosphorylcholine. Thus, the myeloma proteins and normal BALB/c antibodies share similar idiotypic determinants. This experimental system is suitable for probing the role of the antigen receptor in the immune response.

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Year:  1972        PMID： 4113485     DOI： 10.1126/science.176.4038.1027

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  56 in total

1.  Production of antibodies of identical idiotype but diverse immunoglobulin classes by cells derived from a single stimulated B cell.

Authors:  P J Gearhart; N H Sigal; N R Klinman
Journal:  Proc Natl Acad Sci U S A       Date:  1975-05       Impact factor: 11.205

2.  A simple model for the immune network.

Authors:  G Parisi
Journal:  Proc Natl Acad Sci U S A       Date:  1990-01       Impact factor: 11.205

Review 3.  Myeloma proteins.

Authors:  M Potter
Journal:  Experientia       Date:  1986-09-15

4.  Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 streptococcus pneumoniae.

Authors:  D E Briles; M Nahm; K Schroer; J Davie; P Baker; J Kearney; R Barletta
Journal:  J Exp Med       Date:  1981-03-01       Impact factor: 14.307

5.  Expression and rearrangement of homologous immunoglobulin VH genes in two mouse strains.

Authors:  R I Near; E C Juszczak; S Y Huang; S A Sicari; M N Margolies; M L Gefter
Journal:  Proc Natl Acad Sci U S A       Date:  1984-04       Impact factor: 11.205

6.  Anti-thymocyte serum may enhance or suppress the response to the same antigenic determinant.

Authors:  W J Hopkins
Journal:  Immunology       Date:  1975-11       Impact factor: 7.397

7.  The immune response in NZB mice of different ages to thymus-dependent and thymus-independent phosphorylcholine antigens.

Authors:  J P McKearn; G W Miller; J Quintáns
Journal:  Immunology       Date:  1978-06       Impact factor: 7.397

8.  Naturally occurring human antibodies to the F(ab')2 portion of IgG.

Authors:  H Nasu; D S Chia; D W Knutson; E V Barnett
Journal:  Clin Exp Immunol       Date:  1980-11       Impact factor: 4.330

9.  Individual clones of carrier-specific T cells help idiotypically and isotypically heterogeneous anti-hapten B-cell responses.

Authors:  S Cammisuli; M H Schreier
Journal:  Immunology       Date:  1981-07       Impact factor: 7.397

10.  Specific suppression of the antibody response by antibodies to receptors.

Authors:  H Cosenza; H Köhler
Journal:  Proc Natl Acad Sci U S A       Date:  1972-09       Impact factor: 11.205
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