Literature DB >> 7252411

Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 streptococcus pneumoniae.

D E Briles, M Nahm, K Schroer, J Davie, P Baker, J Kearney, R Barletta.   

Abstract

The antiphosphocholine (PC) antibody in normal mouse sera (NMS) provides protection against intravenous infection with encapsulated strain WU2 of type 3 Streptococcus pneumoniae. Mice unable to make anti-PC antibody, as a result of suppression with anti-T-15 idiotype or inheritance of the xid gene of CAB/N mice, are highly susceptible to infection with strain WU2. Mice inheriting the xid gene can be protected with NMS from immunologically normal mice or with IgM hybridoma anti-PC antibody. The protective effect of NMS can be removed with PC-containing immunoabsorbents.

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Year:  1981        PMID： 7252411      PMCID： PMC2186108          DOI： 10.1084/jem.153.3.694

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  50 in total

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Authors:  R J Dubos
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Journal:  J Exp Med       Date:  1979-04-01       Impact factor: 14.307

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  216 in total

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4.  Peritoneal culture alters Streptococcus pneumoniae protein profiles and virulence properties.

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5.  Contribution of serotype and genetic background to virulence of serotype 3 and serogroup 11 pneumococcal isolates.

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6.  Murine monoclonal antibodies specific for virulent Treponema pallidum (Nichols).

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7.  Determination of antibodies to pneumococcal C polysaccharide in patients with community-acquired pneumonia.

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Review 9.  The protective function of human C-reactive protein in mouse models of Streptococcus pneumoniae infection.

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10.  Protective humoral response against pneumococcal infection in mice elicited by recombinant bacille Calmette-Guérin vaccines expressing pneumococcal surface protein A.

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