Literature DB >> 4096305

The effect of tiaprofenic acid and indomethacin on in vitro prostaglandin synthesis by rat, rabbit and human stomach tissue.

J Y Jeremy, D P Mikhailidis, P Dandona.   

Abstract

We compared the inhibitory effect of two non-steroidal anti-inflammatory drugs (NSAIDs), tiaprofenic acid and indomethacin, on in vitro prostaglandin (PG) synthesis by human, rat and rabbit stomach/duodenal tissue. Both drugs were equipotent inhibitors of PGE2, 6-oxo-PGF1 alpha (the stable metabolite of prostacyclin, PGI2) and PGF2 alpha. These findings suggest that tiaprofenic acid does not offer 'gastric protection' by sparing the cytoprotective PGs, as previously claimed. Our in vitro findings are in agreement with the results of clinical trials which show that faecal blood loss and epigastric discomfort are of a similar pattern whether tiaprofenic acid or other NSAIDs are administered.

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Year:  1985        PMID： 4096305     DOI： 10.1007/BF01966593

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  22 in total

1.  Non-steroidal analgesic and anti-inflammatory agents.

Authors:  G Nuki
Journal:  Br Med J (Clin Res Ed)       Date:  1983-07-02

2.  Statistical guidelines for contributors to medical journals.

Authors:  D G Altman; S M Gore; M J Gardner; S J Pocock
Journal:  Br Med J (Clin Res Ed)       Date:  1983-05-07

3.  The misuse of cimetidine in patients with cirrhosis.

Authors:  D P Mikhailidis; M A Barradas; J Christofides; J Y Jeremy; P Dandona
Journal:  Hepatology       Date:  1984 May-Jun       Impact factor: 17.425

4.  Tiaprofenic acid (Surgam) - a major claim is dropped.

Authors: 
Journal:  Drug Ther Bull       Date:  1983-07-01

5.  Antisecretory and protective properties of prostaglandin analogs in man.

Authors:  P Müller; B Simon; H G Dammann
Journal:  Dig Dis Sci       Date:  1982-09       Impact factor: 3.199

6.  Treatment of cyclophosphamide-induced cystitis with prostaglandin E2.

Authors:  J Mohiuddin; H G Prentice; S Schey; H Blacklock; P Dandona
Journal:  Ann Intern Med       Date:  1984-07       Impact factor: 25.391

7.  Aspirin-induced gastric ulcers in cats. Prevention by prostacyclin.

Authors:  S J Konturek; T Radecki; T Brzozowski; I Piastucki; A Zmuda; A Dembińska-Kieć
Journal:  Dig Dis Sci       Date:  1981-11       Impact factor: 3.199

8.  The effect of tiaprofenic acid and indomethacin on vascular prostacyclin and platelet thromboxane A2 production.

Authors:  J Y Jeremy; M A Barradas; D P Mikhailidis; P Dandona
Journal:  Pharmatherapeutica       Date:  1985

9.  Different sensitivities of prostaglandin-cyclooxygenases in blood platelets and coronary arteries against non-steroidal antiinflammatory drugs.

Authors:  K Schrör; S Sauerland; A Kuhn; R Rösen
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1980-08       Impact factor: 3.000

10.  Distribution of prostaglandins in gastric and duodenal mucosa of healthy subjects and duodenal ulcer patients: effects of aspirin and paracetamol.

Authors:  S J Konturek; W Obtulowicz; E Sito; J Oleksy; S Wilkon; A Kiec-Dembinska
Journal:  Gut       Date:  1981-04       Impact factor: 23.059
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  8 in total

1.  Effects of the prodrug nabumetone, and its active metabolite, 6-MNA, on human and rat gastric mucosal prostanoids and platelet function.

Authors:  J Y Jeremy; D P Mikhailidis; M A Barradas; R M Kirk; P Dandona
Journal:  Drugs       Date:  1990       Impact factor: 9.546

2.  Proceedings of the British Pharmacological Society. Leeds, 12th-14th July 1989. Abstracts.

Authors: 
Journal:  Br J Pharmacol       Date:  1989-10       Impact factor: 8.739

3.  Nonsteroidal anti-inflammatory drug therapy and gastric side effects. Does nabumetone provide a solution?

Authors:  P Dandona; J Y Jeremy
Journal:  Drugs       Date:  1990       Impact factor: 9.546

4.  Measurement of arachidonate and its metabolites extracted from human normal and malignant gastrointestinal tissues.

Authors:  A Bennett; A Civier; C N Hensby; P B Melhuish; I F Stamford
Journal:  Gut       Date:  1987-03       Impact factor: 23.059

5.  Involvement of protein kinase C in the control of microvascular permeability to colloidal carbon.

Authors:  A M Northover; B J Northover
Journal:  Agents Actions       Date:  1993-07

6.  Differential regional changes of prostacyclin and thromboxane A2 synthesis in the intestinal tract of the fasted and semistarved rat.

Authors:  J Y Jeremy; C S Thompson; P Dandona
Journal:  Pflugers Arch       Date:  1987-01       Impact factor: 3.657

7.  Stimulation of protein kinase C activity may increase microvascular permeability to colloidal carbon via alpha-isoenzyme.

Authors:  A M Northover; B J Northover
Journal:  Inflammation       Date:  1994-10       Impact factor: 4.092

Review 8.  Tiaprofenic acid. A reappraisal of its pharmacological properties and use in the management of rheumatic diseases.

Authors:  G L Plosker; A J Wagstaff
Journal:  Drugs       Date:  1995-12       Impact factor: 9.546
  8 in total

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