Literature DB >> 4087270

Studies on the effect of low dose methotrexate on rat adjuvant arthritis.

W L Welles, J Silkworth, A L Oronsky, S S Kerwar, J Galivan.   

Abstract

Adjuvant arthritis in rats was induced by the intradermal administration of Freund's complete adjuvant. When these immunized rats were treated orally with low doses of methotrexate (150-600 micrograms/kg/week) a statistically significant suppression of paw inflammation was observed. This low dose of methotrexate was comparable to that used in the treatment of human rheumatoid arthritis (RA). Our results are the first demonstration of the efficacy of low dose methotrexate in an animal model of human RA.

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Year:  1985        PMID： 4087270

Source DB:  PubMed          Journal:  J Rheumatol        ISSN： 0315-162X            Impact factor:   4.666


  14 in total

Review 1.  Molecular mechanism of methotrexate action in inflammation.

Authors:  B N Cronstein
Journal:  Inflammation       Date:  1992-10       Impact factor: 4.092

2.  In vitro effects of methotrexate on peripheral blood monocytes: modulation by folinic acid and S-adenosylmethionine.

Authors:  G Nesher; T L Moore; R W Dorner
Journal:  Ann Rheum Dis       Date:  1991-09       Impact factor: 19.103

3.  Tumour necrosis factor (TNF) production by T cell receptor-primed T lymphocytes is a target for low dose methotrexate in rheumatoid arthritis.

Authors:  K Hildner; S Finotto; C Becker; J Schlaak; P Schirmacher; P R Galle; E Märker-Hermann; M F Neurath
Journal:  Clin Exp Immunol       Date:  1999-10       Impact factor: 4.330

4.  The effect of methotrexate on lipoxygenase metabolism in neutrophils from rats: in vitro and ex vivo studies.

Authors:  J S Hawkes; L G Cleland; M J James
Journal:  Agents Actions       Date:  1993-11

5.  Treatment of adjuvant-induced arthritis with the combination of methotrexate and probiotic bacteria Escherichia coli O83 (Colinfant).

Authors:  J Rovenský; M Stancíková; K Svík; J Utesený; K Bauerová; J Jurcovicová
Journal:  Folia Microbiol (Praha)       Date:  2009-10-14       Impact factor: 2.099

6.  Differential effects of methotrexate and liposomally conjugated methotrexate in rat adjuvant-induced arthritis.

Authors:  A S Williams; J P Camilleri; N Amos; B D Williams
Journal:  Clin Exp Immunol       Date:  1995-12       Impact factor: 4.330

Review 7.  Methotrexate in rheumatoid arthritis. An update.

Authors:  B Bannwarth; L Labat; Y Moride; T Schaeverbeke
Journal:  Drugs       Date:  1994-01       Impact factor: 9.546

8.  Long-term treatment of the MRL/lpr mouse with methotrexate and 10-deazaaminopterin.

Authors:  J E Baggott; S L Morgan; L E Freeberg; B B Hudson; W H Vaughn; M Gopal Nair; C L Krumdieck; W J Koopman; R E Gay; S Gay
Journal:  Agents Actions       Date:  1992-01

9.  Methotrexate treatment ameliorated testicular suppression and anorexia related leptin reduction in rats with adjuvant arthritis.

Authors:  Jana Jurcovicova; Karol Svik; Sona Scsukova; Katarina Bauerova; Jozef Rovensky; Maria Stancikova
Journal:  Rheumatol Int       Date:  2009-01-21       Impact factor: 2.631

10.  Treatment of experimental adjuvant arthritis with the combination of methotrexate and lyophilized Enterococcus faecium enriched with organic selenium.

Authors:  J Rovenský; K Svík; M Stancíková; R Istok; L Ebringer; M Ferencík
Journal:  Folia Microbiol (Praha)       Date:  2002       Impact factor: 2.099
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