Literature DB >> 4085911

Inhibitors of collagenolytic enzymes in the serum of patients with chronic liver disorders.

E J Kucharz.   

Abstract

Inhibitory effect of serum on collagenolysis was studied in rat hepatic slices. Sera of patients with cirrhosis contained low concentrations of inhibitors. Higher concentrations were found in sera from patients with chronic active hepatitis and chronic persistent hepatitis, than in healthy individuals. It is suggested that changes of the serum inhibitory activity are responsible for the control of collagen degradation in the injured liver.

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Year:  1985        PMID： 4085911      PMCID： PMC1433104          DOI： 10.1136/gut.26.12.1364

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  16 in total

1.  A colorimetric micromethod for determination of hydroxyproline in blood serum.

Authors:  M Drózdz; E Kucharz; J Szyja
Journal:  Z Med Labortech       Date:  1976-08-04

2.  Collagenase activity in experimental hepatic fibrosis.

Authors:  I Okazaki; K Maruyama
Journal:  Nature       Date:  1974-11-01       Impact factor: 49.962

3.  Solubilization of collagen fibrils by human leucocyte collagenase activated by rheumatoid synovial fluid.

Authors:  I Sopata; E Wojtecka-Lukasik; A M Dancewicz
Journal:  Acta Biochim Pol       Date:  1974       Impact factor: 2.149

4.  Cirrhosis associated with alpha-1-antitrypsin deficiency: a previously unrecognized inherited disorder.

Authors:  H L Sharp; R A Bridges; W Krivit; E F Freier
Journal:  J Lab Clin Med       Date:  1969-06

5.  [Alpha-1 antitrypsin, alpha-2-macroglobulin and antiplasmin activity in liver and bile tract diseases].

Authors:  J Bogdal; K Cichecka; A Jedrychowski
Journal:  Pol Tyg Lek       Date:  1973-06-25

6.  On the hormonal modulation of acute-phase plasma protein synthesis in perfused rat liver.

Authors:  A Koj; A Dubin
Journal:  Acta Biochim Pol       Date:  1974       Impact factor: 2.149

7.  Clinical and experimental studies on collagen metabolism in hepatic disorders.

Authors:  E Kucharz
Journal:  Med Interne       Date:  1984 Apr-Jun

8.  [Endogenous inhibitors of fibrinolytic activity in liver cirrhosis (author's transl)].

Authors:  R Aschauer; F Holzknecht; S Platzer
Journal:  Klin Wochenschr       Date:  1973-12-01

9.  Small molecular weight beta 1 serum protein which specifically inhibits human collagenases.

Authors:  D E Woolley; D R Roberts; J M Evanson
Journal:  Nature       Date:  1976-05-27       Impact factor: 49.962

10.  Collagenase and its natural inhibitors in relation to the rheumatoid joint.

Authors:  D E Woolley; J M Evanson
Journal:  Connect Tissue Res       Date:  1977       Impact factor: 3.417
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