Literature DB >> 4085527

1H nuclear magnetic resonance study of metronidazole metabolism by perfused rat liver.

H Allars, M D Coleman, R S Norton.   

Abstract

High-resolution 1H nuclear magnetic resonance (NMR) spectroscopy at 300 MHz has been used to monitor the metabolism of metronidazole by the perfused rat liver. Samples of perfusate removed at various times during the perfusion show resonances from metronidazole and its major metabolites, as well as those from organic metabolites released from the liver. The major metabolite of metronidazole is shown to be its glucuronide conjugate. Metronidazole metabolism and glucuronide production are both stimulated in livers from rats pretreated with phenobarbitone.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 4085527     DOI： 10.1007/BF03189750

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN： 0378-7966            Impact factor:   2.441


  22 in total

1.  Nutritional aspects of amino acid metabolism. 1. A rat liver perfusion method for the study of amino acid metabolism.

Authors:  D L Bloxam
Journal:  Br J Nutr       Date:  1971-11       Impact factor: 3.718

2.  Isolated perfused rat liver technique.

Authors:  D K Meijer; K Keulemans; G J Mulder
Journal:  Methods Enzymol       Date:  1981       Impact factor: 1.600

3.  The reductive metabolism of metronidazole and ronidazole by aerobic liver microsomes.

Authors:  E Perez-Reyes; B Kalyanaraman; R P Mason
Journal:  Mol Pharmacol       Date:  1980-03       Impact factor: 4.436

Review 4.  Drug therapy: metronidazole.

Authors:  J Koch-Weser; P Goldman
Journal:  N Engl J Med       Date:  1980-11-20       Impact factor: 91.245

5.  Binding of metronidazole and its derivatives to plasma proteins: an assessment of drug binding phenomenon.

Authors:  D R Sanvordeker; Y W Chien; T K Lin; H J Lambert
Journal:  J Pharm Sci       Date:  1975-11       Impact factor: 3.534

6.  Pharmacokinetics and metabolic disposition of 14C-metronidazole-derived radioactivity in rat after intravenous and intravaginal administration.

Authors:  H S Buttar; W H Siddiqui
Journal:  Arch Int Pharmacodyn Ther       Date:  1980-05

7.  Species differences in the disposition and metabolism of 1-methyl-3-(3-pyridyl)-5-(2-hydroxy-methylphenyl)-1H-1,2,4-triazole, a potential sedative-hypnotic compound.

Authors:  A Assandri; A Omodei-Salè; P Ferrari; G Tuan; A Perazzi; A Ripamonti; E Martinelli
Journal:  Xenobiotica       Date:  1982-01       Impact factor: 1.908

8.  The mechanism of binding of the radiosensitizers metronidazole and misonidazole (Ro-07-0582) to bovine and human serum albumin--a proton NMR study.

Authors:  A Sułkowska; B Lubas; T Wilczok
Journal:  Radiat Res       Date:  1981-01       Impact factor: 2.841

Review 9.  Metronidazole (Flagyl IV, Searle).

Authors:  M H Stranz; W E Bradley
Journal:  Drug Intell Clin Pharm       Date:  1981-11

10.  Metronidazole (Flagyl): characterization as a cytotoxic drug specific for hypoxic tumour cells.

Authors:  J L Foster; P J Conroy; A J Searle; R L Willson
Journal:  Br J Cancer       Date:  1976-05       Impact factor: 7.640
View more
  1 in total

Review 1.  NMR studies of drug metabolism and disposition.

Authors:  J D Bell; D G Gadian; N E Preece
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1990 Apr-Jun       Impact factor: 2.441
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.