Literature DB >> 4073876

Effect of ketoconazole in combination with other inhibitors of sterol synthesis on fungal growth.

I J Sud, D S Feingold.   

Abstract

The effect of combination of ketoconazole with other sterol synthesis inhibitors on fungal growth was tested against a variety of fungi selected for resistance to ketoconazole. All of the sterol inhibitors, at concentrations lower than their MICs, caused an increase greater than fourfold in the ketoconazole susceptibility of some fungi. Some of the sterol synthesis inhibitors showed this effect with ketoconazole at levels that may be achieved clinically.

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Year:  1985        PMID： 4073876      PMCID： PMC180299          DOI： 10.1128/AAC.28.4.532

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

1.  Biochemical effects of miconazole on fungi. II. Inhibition of ergosterol biosynthesis in Candida albicans.

Authors:  H van den Bossche; G Willemsens; W Cools; W F Lauwers; L Le Jeune
Journal:  Chem Biol Interact       Date:  1978-04       Impact factor: 5.192

2.  Obfuscation of the activity of antifungal antimicrobics by culture media.

Authors:  P D Hoeprich; P D Finn
Journal:  J Infect Dis       Date:  1972-10       Impact factor: 5.226

3.  Ketoconazole and the liver.

Authors:  C R Horseburgh; C H Kirkpatrick; C B Teutsch
Journal:  Lancet       Date:  1982-04-10       Impact factor: 79.321

4.  Heterogeneity of action of mechanisms among antimycotic imidazoles.

Authors:  I J Sud; D S Feingold
Journal:  Antimicrob Agents Chemother       Date:  1981-07       Impact factor: 5.191

5.  Azole resistance in Candida albicans.

Authors:  J F Ryley; R G Wilson; K J Barrett-Bee
Journal:  Sabouraudia       Date:  1984

6.  Inhibition of sterol biosynthesis in Candida albicans by imidazole-containing antifungals.

Authors:  M S Marriott
Journal:  J Gen Microbiol       Date:  1980-03

7.  Specific effects of triarimol on sterol biosynthesis in Ustilago maydis.

Authors:  N N Ragsdale
Journal:  Biochim Biophys Acta       Date:  1975-01-24

8.  Selective membrane toxicity of the polyene antibiotics: studies on lecithin membrane models (liposomes).

Authors:  C C Hsuchen; D S Feingold
Journal:  Antimicrob Agents Chemother       Date:  1973-09       Impact factor: 5.191

9.  Antimicrobial susceptibility testing of yeasts: a turbidimetric technique independent of inoculum size.

Authors:  J N Galgiani; D A Stevens
Journal:  Antimicrob Agents Chemother       Date:  1976-10       Impact factor: 5.191

10.  Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.

Authors:  A W Alberts; J Chen; G Kuron; V Hunt; J Huff; C Hoffman; J Rothrock; M Lopez; H Joshua; E Harris; A Patchett; R Monaghan; S Currie; E Stapley; G Albers-Schonberg; O Hensens; J Hirshfield; K Hoogsteen; J Liesch; J Springer
Journal:  Proc Natl Acad Sci U S A       Date:  1980-07       Impact factor: 11.205
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  3 in total

1.  Antiproliferative synergism of the allylamine SF 86-327 and ketoconazole on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi.

Authors:  J A Urbina; K Lazardi; T Aguirre; M M Piras; R Piras
Journal:  Antimicrob Agents Chemother       Date:  1988-08       Impact factor: 5.191

2.  Effects of lovastatin (mevinolin) on sterol levels and on activity of azoles in Saccharomyces cerevisiae.

Authors:  R T Lorenz; L W Parks
Journal:  Antimicrob Agents Chemother       Date:  1990-09       Impact factor: 5.191

3.  Photoinactivation of Candida albicans by its own endogenous porphyrins.

Authors:  Sarit Oriel; Yeshayahu Nitzan
Journal:  Curr Microbiol       Date:  2009-10-01       Impact factor: 2.188
  3 in total

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