Literature DB >> 6993625

Inhibition of sterol biosynthesis in Candida albicans by imidazole-containing antifungals.

M S Marriott.   

Abstract

A simple procedure for studying sterol biosynthesis in cell-free homogenates of Candida albicans is described. The activities of some imidazole-containing antifungals (tioconazole, clotrimazole, econazole, ketoconazole and miconazole) as inhibitors of sterol C-14 demethylation have been determined using this technique.

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Year:  1980        PMID： 6993625     DOI： 10.1099/00221287-117-1-253

Source DB:  PubMed          Journal:  J Gen Microbiol        ISSN： 0022-1287


  29 in total

1.  Itraconazole-amphotericin B antagonism in Aspergillus fumigatus: an E-test-based strategy.

Authors:  D P Kontoyiannis; R E Lewis; N Sagar; G May; R A Prince; K V Rolston
Journal:  Antimicrob Agents Chemother       Date:  2000-10       Impact factor: 5.191

2.  Comparison of D0870, a new triazole antifungal agent, to fluconazole for inhibition of Candida albicans cytochrome P-450 by using in vitro assays.

Authors:  K Venkateswarlu; D W Denning; N J Manning; S L Kelly
Journal:  Antimicrob Agents Chemother       Date:  1996-06       Impact factor: 5.191

Review 3.  Clinical, cellular, and molecular factors that contribute to antifungal drug resistance.

Authors:  T C White; K A Marr; R A Bowden
Journal:  Clin Microbiol Rev       Date:  1998-04       Impact factor: 26.132

4.  The presence of an R467K amino acid substitution and loss of allelic variation correlate with an azole-resistant lanosterol 14alpha demethylase in Candida albicans.

Authors:  T C White
Journal:  Antimicrob Agents Chemother       Date:  1997-07       Impact factor: 5.191

5.  Fungicidal activity of tioconazole in relation to growth phase of Candida albicans and Candida parapsilosis.

Authors:  W H Beggs
Journal:  Antimicrob Agents Chemother       Date:  1984-11       Impact factor: 5.191

6.  Effect of the antimycotic drug naftifine on growth of and sterol biosynthesis in Candida albicans.

Authors:  N S Ryder; G Seidl; P F Troke
Journal:  Antimicrob Agents Chemother       Date:  1984-04       Impact factor: 5.191

7.  Cytochrome P-450-dependent 14 alpha-demethylation of lanosterol in Candida albicans.

Authors:  C A Hitchcock; S B Brown; E G Evans; D J Adams
Journal:  Biochem J       Date:  1989-06-01       Impact factor: 3.857

8.  Growth phase in relation to ketoconazole and miconazole susceptibilities of Candida albicans.

Authors:  W H Beggs
Journal:  Antimicrob Agents Chemother       Date:  1984-03       Impact factor: 5.191

9.  Effect of antifungal agents on lipid biosynthesis and membrane integrity in Candida albicans.

Authors:  N H Georgopapadakou; B A Dix; S A Smith; J Freudenberger; P T Funke
Journal:  Antimicrob Agents Chemother       Date:  1987-01       Impact factor: 5.191

10.  Primary site of action of ketoconazole on Candida albicans.

Authors:  J Uno; M L Shigematsu; T Arai
Journal:  Antimicrob Agents Chemother       Date:  1982-06       Impact factor: 5.191
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