Literature DB >> 4070019

An increase in startle response in rats administered oxytocin.

M G King, R Brown, A Kusnecov.   

Abstract

Twenty-four male albino Wistar rats were allocated to four groups and given either 23.2, 11.6 or 5.8 IU OXT/kg or vehicle (0.9% saline). A significant increase in startle response was observed in the 11.6 and 5.8 IU OXT/kg groups when compared to vehicle. Our results further support the suggestion that OXT is a "stress hormone" by implicating this peptide with increased emotionality/reactivity during a stressful experience.

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Year:  1985        PMID: 4070019     DOI: 10.1016/0196-9781(85)90122-6

Source DB:  PubMed          Journal:  Peptides        ISSN: 0196-9781            Impact factor:   3.750


  3 in total

1.  Oxytocin reduces background anxiety in a fear-potentiated startle paradigm.

Authors:  Galen Missig; Luke W Ayers; Jay Schulkin; Jeffrey B Rosen
Journal:  Neuropsychopharmacology       Date:  2010-09-15       Impact factor: 7.853

2.  Effects of oxytocin on background anxiety in rats with high or low baseline startle.

Authors:  Luke Ayers; Andrew Agostini; Jay Schulkin; Jeffrey B Rosen
Journal:  Psychopharmacology (Berl)       Date:  2016-03-23       Impact factor: 4.530

3.  Does trait anxiety influence effects of oxytocin on eye-blink startle reactivity? A randomized, double-blind, placebo-controlled crossover study.

Authors:  Sonja Schumacher; Misari Oe; Frank H Wilhelm; Michael Rufer; Markus Heinrichs; Steffi Weidt; Hanspeter Moergeli; Chantal Martin-Soelch
Journal:  PLoS One       Date:  2018-01-04       Impact factor: 3.240

  3 in total

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