| Literature DB >> 4067988 |
P W Sprague, J E Heikes, J Z Gougoutas, M F Malley, D N Harris, R Greenberg.
Abstract
A series of chemically stable TXA2/PGH2 analogues modeled after the structure of the natural products was prepared in search of useful inhibitors of TXA2/PGH2-mediated pathophysiology. Each of the 16 isomers implied in structure 1 was prepared in chiral form and evaluated for activity in vitro in platelets and smooth muscle. Depending on relative side chain and carbinol stereochemistry, TXA2/PGH2 agonist and antagonist and, surprisingly, PGD2/PGI2 agonist activities were observed. The enantiomers possessing the alpha heterocycle shown in 1 were generally more potent than their mirror-image isomers.Entities:
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Year: 1985 PMID： 4067988 DOI： 10.1021/jm00149a007
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446