Literature DB >> 406635

Lethal effects of physostigmine plus lithium in rats.

J R Samples, D S Janowsky, R Pechnick, L L Judd.   

Abstract

The interaction between the reversible cholinesterase inhibitor, physostigmine, and lithium chloride was studied in adult male rats. A combination of lithium plus physostigmine increased lethality more than that caused by either physostigmine or lithium alone. Scopolamine completely reversed this effect. These drug interactions may have clinical significance, since lithium plus cholinesterase inhibitors may be used together in the practice of medicine.

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Year:  1977        PMID: 406635     DOI: 10.1007/bf00426716

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN: 0033-3158            Impact factor:   4.530


  11 in total

1.  Lethal effects of reserpine plus physostigmine and neostigmine in mice.

Authors:  D Janowsky; R Pechnick; E Janowsky
Journal:  Clin Exp Pharmacol Physiol       Date:  1976 Sep-Oct       Impact factor: 2.557

2.  A cholinergic-adrenergic hypothesis of mania and depression.

Authors:  D S Janowsky; M K el-Yousef; J M Davis; H J Sekerke
Journal:  Lancet       Date:  1972-09-23       Impact factor: 79.321

3.  The effects of lithium and physostigmine on rat brain acetylcholinesterase activity.

Authors:  L L Simpson
Journal:  Psychopharmacologia       Date:  1974

4.  Parasympathetic suppression of manic symptoms by physostigmine.

Authors:  D S Janowsky; K el-Yousef; J M Davis; H J Sekerke
Journal:  Arch Gen Psychiatry       Date:  1973-04

5.  Effect of lithium on acetylcholine release and synthesis.

Authors:  E S Vizi; P Illés; A Rónai; J Knoll
Journal:  Neuropharmacology       Date:  1972-07       Impact factor: 5.250

6.  The effects of lthium salts on the turnover and metabolism of norepinephrine in rat brain.

Authors:  J J Schildkraut; M A Logue; G A Dodge
Journal:  Psychopharmacologia       Date:  1969

7.  A biphasic action of central cholinergic stimulation on behavioral arousal in the rat.

Authors:  H C Fibiger; G S Lynch; H P Cooper
Journal:  Psychopharmacologia       Date:  1971

8.  Emergence of myasthenia gravis during treatment with lithium carbonate.

Authors:  J F Neil; J M Himmelhoch; S M Licata
Journal:  Arch Gen Psychiatry       Date:  1976-09

9.  Acetylcholine release from the rabbit isolated superior cervical ganglion preparation.

Authors:  P M Dawes; E S Vizi
Journal:  Br J Pharmacol       Date:  1973-06       Impact factor: 8.739

10.  Evoked release of norepinephrine and serotonin from brain slices: inhibitoon by lithium.

Authors:  R I Katz; T N Chase; I J Kopin
Journal:  Science       Date:  1968-10-25       Impact factor: 47.728

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  2 in total

1.  Lithium administration antagonizes cholinergic behavioral effects in rodents.

Authors:  D S Janowsky; A A Abrams; G P Groom; L L Judd; P Cloptin
Journal:  Psychopharmacology (Berl)       Date:  1979-05-25       Impact factor: 4.530

2.  Circadian rhythm of lithium toxicity in mice.

Authors:  R Hawkins; D F Kripke; D S Janowsky
Journal:  Psychopharmacology (Berl)       Date:  1978-01-31       Impact factor: 4.530

  2 in total

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