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Literature DB >> 112633

Lithium administration antagonizes cholinergic behavioral effects in rodents.

D S Janowsky, A A Abrams, G P Groom, L L Judd, P Cloptin.

Abstract

Physostigmine, a centrally acting cholinesterase inhibitor, antagonizes methylphenidate-induced stereotyped gnawing behavior in mice and rats. This effect is significantly attenuated when lithium chloride is concurrently administered, indicating that lithium chloride may antagonize central cholinergic activity. This observation may have theoretical implications for an adrenergic-cholinergic balance hypothesis of affective disorders.

Entities: Chemical Gene Species

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Year: 1979 PMID： 112633 DOI： 10.1007/bf00429693

Source DB: PubMed Journal: Psychopharmacology (Berl) ISSN： 0033-3158 Impact factor: 4.530

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References

17 in total

1. EFFECTS OF CHOLINERGIC DRUGS ON HYPOTHALAMIC SELF-STIMULATION RESPONSE RATES OF DOGS.

Authors: P STARK; E S BOYD
Journal: Am J Physiol Date: 1963-10

2. Modification by lithium of transmitter release at the neuromuscular junction of the frog.

Authors: D D Branisteanu; R L Volle
Journal: J Pharmacol Exp Ther Date: 1975-08 Impact factor: 4.030

3. The effects of lithium on the neuromuscular junction of the frog.

Authors: K Onodera; K Yamakawa
Journal: Jpn J Physiol Date: 1966-10-15

4. Proceedings: A selective excitatory effect of lithium on cholinoceptive neurones in the spinal cord and brain of cats and rats: a possible significance in manic-depression.

Authors: H L Haas; R W Ryall
Journal: Br J Pharmacol Date: 1974-11 Impact factor: 8.739

Lithium administration antagonizes cholinergic behavioral effects in rodents.

1. EFFECTS OF CHOLINERGIC DRUGS ON HYPOTHALAMIC SELF-STIMULATION RESPONSE RATES OF DOGS.

2. Modification by lithium of transmitter release at the neuromuscular junction of the frog.

3. The effects of lithium on the neuromuscular junction of the frog.

4. Proceedings: A selective excitatory effect of lithium on cholinoceptive neurones in the spinal cord and brain of cats and rats: a possible significance in manic-depression.

5. The effects of lithium and physostigmine on rat brain acetylcholinesterase activity.

6. Induction of severe depression by physostigmine in marihuana intoxicated individuals.

7. Effect of lithium on acetylcholine release and synthesis.

8. Depression associated with oral choline.

9. Actions of lithium ions in mammalian sympathetic ganglia.

10. Physostigmine: effects on cognition and affect in normal subjects.