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Literature DB >> 4061566

Acute colitis produced by chemotactic peptides in rats and mice.

J F Chester, J S Ross, R A Malt, S A Weitzman.

Abstract

Colonic inflammation was produced in rats and mice by peptides chemotactic for polymorphonuclear leukocytes. Instillation of formylmethionyl-leucyl-phenylalanine (FMLP) and formylnorleucyl-leucyl-phenylalanine (FNLP) into isolated segments of rat colon caused marked mucosal edema and polymorphonuclear leukocyte infiltration within 2 hours. Higher concentrations of FNLP caused ulceration and necrosis as well. Formylmethionine (FMet), a compound with less chemotactic activity, caused much less inflammation. In mice, rectal instillation of FNLP caused dose-dependent acute mucosal inflammation which persisted for longer than 12 hours. Twice-weekly rectal instillation of FNLP provided a model of colitis based on neutrophil chemotaxis.

Entities: Chemical Disease Species

Mesh：

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Year: 1985 PMID： 4061566 PMCID： PMC1888052

Source DB: PubMed Journal: Am J Pathol ISSN： 0002-9440 Impact factor: 4.307

36 in total

1. Spasmogenic activity of chemotactic N-formylated oligopeptides: identity of structure--function relationships for chemotactic and spasmogenic activities.

Authors: W A Marasco; J C Fantone; P A Ward
Journal: Proc Natl Acad Sci U S A Date: 1982-12 Impact factor: 11.205

2. Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions.

Authors: J C Fantone; P A Ward
Journal: Am J Pathol Date: 1982-06 Impact factor: 4.307

3. The role of oxygen free radicals in human disease processes.

Authors: G B Bulkley
Journal: Surgery Date: 1983-09 Impact factor: 3.982

4. Purification and identification of formyl-methionyl-leucyl-phenylalanine as the major peptide neutrophil chemotactic factor produced by Escherichia coli.

Authors: W A Marasco; S H Phan; H Krutzsch; H J Showell; D E Feltner; R Nairn; E L Becker; P A Ward
Journal: J Biol Chem Date: 1984-05-10 Impact factor: 5.157

5. The in vivo effect of leukotriene B4 on polymorphonuclear leukocytes and the microcirculation. Comparison with activated complement (C5a des Arg) and enhancement by prostaglandin E2.

Authors: H Z Movat; C Rettl; C E Burrowes; M G Johnston
Journal: Am J Pathol Date: 1984-05 Impact factor: 4.307

6. Biosynthesis of lipoxygenase and cyclo-oxygenase products from [14C]-arachidonic acid by human colonic mucosa.

Authors: N K Boughton-Smith; C J Hawkey; B J Whittle
Journal: Gut Date: 1983-12 Impact factor: 23.059

7. Chemotaxis and random migration of polymorphonuclear leukocytes in ulcerative colitis examined by the agarose method.

Authors: A Hermanowicz; Z Nawarska
Journal: Scand J Gastroenterol Date: 1981 Impact factor: 2.423

8. Proteases and oxidants in experimental pulmonary inflammatory injury.

Authors: I U Schraufstätter; S D Revak; C G Cochrane
Journal: J Clin Invest Date: 1984-04 Impact factor: 14.808

9. The superoxide free radical: its biochemistry and pathophysiology.

Authors: J M McCord
Journal: Surgery Date: 1983-09 Impact factor: 3.982

Review 10. Role of oxygen-derived free radicals in digestive tract diseases.

Authors: D A Parks; G B Bulkley; D N Granger
Journal: Surgery Date: 1983-09 Impact factor: 3.982

22 in total

1. Human neutrophil formyl peptide receptor phosphorylation and the mucosal inflammatory response.

Authors: Giovanna Leoni; Jeannie Gripentrog; Connie Lord; Marcia Riesselman; Ronen Sumagin; Charles A Parkos; Asma Nusrat; Algirdas J Jesaitis
Journal: J Leukoc Biol Date: 2014-11-13 Impact factor: 4.962

Review 2. Inflammatory intermediaries in inflammatory bowel disease.

Authors: K Lauritsen; L S Laursen; K Bukhave; J Rask-Madsen
Journal: Int J Colorectal Dis Date: 1989 Impact factor: 2.571

3. Effect of bacterial chemotactic peptides on intestinal inflammation in animal models of acute and chronic "relapsed" colitis.

Authors: Gerardo A Hernández; Melanie R Valentín; Caroline B Appleyard
Journal: Dig Dis Sci Date: 2005-08 Impact factor: 3.199

Review 4. Development of small molecule non-peptide formyl peptide receptor (FPR) ligands and molecular modeling of their recognition.

Authors: I A Schepetkin; A I Khlebnikov; M P Giovannoni; L N Kirpotina; A Cilibrizzi; M T Quinn
Journal: Curr Med Chem Date: 2014 Impact factor: 4.530

5. Mucosal subepithelial binding sites for the bacterial chemotactic peptide, formyl-methionyl-leucyl-phenylalanine (FMLP).

Authors: P Anton; J O'Connell; D O'Connell; L Whitaker; G C O'Sullivan; J K Collins; F Shanahan
Journal: Gut Date: 1998-03 Impact factor: 23.059