Literature DB >> 4060851

Stability of infectious influenza A viruses at low pH and at elevated temperature.

C Scholtissek.   

Abstract

After treatment of different strains of influenza A at low pH, the threshold pH, at which the infectivity was lost, depended on the haemagglutinin (HA) subtype of the virus strain. Strains with noncleaved HA were much more stable when compared to strains with cleaved HA. These observations might explain why duck influenza viruses spread well by lake water, while highly pathogenic strains with cleaved HA do not. There were also significant differences in heat stability of infectivity among influenza A strains, which do not correlate with differences in stability at low pH.

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Year:  1985        PMID： 4060851     DOI： 10.1016/0264-410x(85)90109-4

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  53 in total

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9.  The pH of activation of the hemagglutinin protein regulates H5N1 influenza virus replication and pathogenesis in mice.

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