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Literature DB >> 406001

Unnecessary polypharmacy for epilepsy.

Abstract

A retrospective survey of 50 adult epileptic outpatients who were taking two anticonvulsants drugs showed that seizure control had improved in the six months after the introduction of the second drug in only 36%. When blood concentrations of the two anticonvulsants were subsequently measured improvement in seizure control was found to be significantly related to the presence of optimum blood concentrations of at least one drug. Much unnecessary polypharmacy in the treatment of epilepsy could be avoided by ensuring an optimum blood concentration of one drug before considering the addition of a second.

Entities: Disease

Mesh：

Substances：
Anticonvulsants

Year: 1977 PMID： 406001 PMCID： PMC1607741 DOI： 10.1136/bmj.1.6077.1635

Source DB: PubMed Journal: Br Med J ISSN： 0007-1447

6 in total

1. Clinical and electroencephalographic correlations with serum levels of diphenylhydanotin.

Authors: F BUCHTHAL; O SVENSMARK; P J SCHILLER
Journal: Arch Neurol Date: 1960-06

2. Chronic antiepileptic toxicity: a review.

Authors: E H Reynolds
Journal: Epilepsia Date: 1975-06 Impact factor: 5.864

Review 3. Usefulness of blood levels of antiepileptic drugs.

Authors: H Kutt; J K Penry
Journal: Arch Neurol Date: 1974-11

4. An isothermal GLC determination of the plasma levels of carbamazepine, diphenylhydantoin, phenobarbitone and primidone.

Authors: P A Toseland; J Grove; D J Berry
Journal: Clin Chim Acta Date: 1972-05 Impact factor: 3.786

5. Anticonvulsant effect of diphenylhydantoin relative to plasma levels. A prospective three-year study in ambulant patients with generalized epileptic seizures.

Authors: L Lund
Journal: Arch Neurol Date: 1974-11

6. One drug (phenytoin) in the treatment of epilepsy.

Authors: E H Reynolds; D Chadwick; A W Galbraith
Journal: Lancet Date: 1976-05-01 Impact factor: 79.321

6 in total

17 in total

1. Reduction in polypharmacy for epilepsy.

Authors: S D Shorvon; E H Reynolds
Journal: Br Med J Date: 1979-10-27

2. The comparative efficacy of antiepileptic drugs for partial and tonic-clonic seizures.

Authors: D Chadwick; D M Turnbull
Journal: J Neurol Neurosurg Psychiatry Date: 1985-11 Impact factor: 10.154

3. Single drug or combination therapy for epilepsy?

Authors: E H Reynolds; S D Shorvon
Journal: Drugs Date: 1981-05 Impact factor: 9.546

4. One drug for epilepsy.

Authors: S D Shorvon; D Chadwick; A W Galbraith; E H Reynolds
Journal: Br Med J Date: 1978-02-25

5. Medical audit of the care of patients with epilepsy in one group practice.

Authors: A L Jones
Journal: J R Coll Gen Pract Date: 1980-07

Review 6. Drug treatment of epilepsy. Outlines, criticism and perspectives.

Authors: E Beghi; R Di Mascio; G Tognoni
Journal: Drugs Date: 1986-03 Impact factor: 9.546

7. Two antiepileptic drugs for intractable epilepsy with complex-partial seizures.

Authors: D Schmidt
Journal: J Neurol Neurosurg Psychiatry Date: 1982-12 Impact factor: 10.154

8. Monotherapy and polytherapy for intractable epilepsies.

Authors: C Cornaggia; M P Canevini; D Giuccioli; P Pinelli; C Pruneri; R Canger
Journal: Ital J Neurol Sci Date: 1985-06

9. Phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed adult epilepsy: a randomised comparative monotherapy trial.

Authors: A J Heller; P Chesterman; R D Elwes; P Crawford; D Chadwick; A L Johnson; E H Reynolds
Journal: J Neurol Neurosurg Psychiatry Date: 1995-01 Impact factor: 10.154

10. Antiepileptic drug monotherapy: the initial approach in epilepsy management.

Authors: Erik K St Louis; William E Rosenfeld; Thomas Bramley
Journal: Curr Neuropharmacol Date: 2009-06 Impact factor: 7.363