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Literature DB >> 4058269

Norflurazon--an inhibitor of essential fatty acid desaturation in isolated liver cells.

Abstract

Norflurazon is a herbicide known to inhibit carotene biosynthesis and linolenic acid biosynthesis in plants. In the present work, the effect of norflurazon on the metabolism of studied in isolated rat liver cells and in rat liver microsomes, incubated with [1-14C] labeled linolenic acid (18:3, n-3), dihomogammalinolenic acid (20:3, n-6) and eicosapentaenoic acid (20:5, n-3). Norflurazon (0.1 mM, 1.0 mM) was found to inhibit essential fatty acid desaturation. The delta 6 desaturation is inhibited more efficiently than the delta 5 and delta 4 desaturation. The chain elongation of essential C18 fatty acids to their C20 and C22 homologs was not inhibited by norflurazon.

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Year: 1985 PMID： 4058269 DOI： 10.1007/BF02534393

Source DB: PubMed Journal: Lipids ISSN： 0024-4201 Impact factor: 1.880

12 in total

1. A simple method for the isolation and purification of total lipides from animal tissues.

Authors: J FOLCH; M LEES; G H SLOANE STANLEY
Journal: J Biol Chem Date: 1957-05 Impact factor: 5.157

2. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

3. Regulation of palmitate metabolism by carnitine and glucagon in hepatocytes isolated from fasted and carbohydrate refed rats.

Authors: R Z Christiansen
Journal: Biochim Biophys Acta Date: 1977-08-24

8. Simultaneous Inhibition of Linolenic Acid Synthesis in Winter Wheat Roots and Frost Hardening by BASF 13-338, a Derivative of Pyridazinone.

Authors: C Willemot
Journal: Plant Physiol Date: 1977-07 Impact factor: 8.340

9. Inhibition of linolenic Acid synthesis and modification of chilling resistance in cotton seedlings.

Authors: J B John; M N Christiansen
Journal: Plant Physiol Date: 1976-02 Impact factor: 8.340

10. Effect of dietary fats on arachidonic acid and eicosapentaenoic acid biosynthesis and conversion to C22 fatty acids in isolated rat liver cells.

Authors: T A Hagve; B O Christophersen
Journal: Biochim Biophys Acta Date: 1984-11-14

1 in total

1. Modulation of fatty acid incorporation and desaturation by trifluoperazine in fungi.

Authors: Y Kamisaka; T Yokochi; T Nakahara; O Suzuki
Journal: Lipids Date: 1990-12 Impact factor: 1.880

1 in total

Norflurazon--an inhibitor of essential fatty acid desaturation in isolated liver cells.

1. A simple method for the isolation and purification of total lipides from animal tissues.

2. Protein measurement with the Folin phenol reagent.

3. Regulation of palmitate metabolism by carnitine and glucagon in hepatocytes isolated from fasted and carbohydrate refed rats.

4. Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion.

5. The preferred metabolic pathway from linoleic acid to arachidonic acid in vitro.

6. Nutritional and hormonal factors influencing desaturation of essential fatty acids.

7. Secretion of lecithin: cholesterol acyltransferase from isolated rat hepatocytes.

8. Simultaneous Inhibition of Linolenic Acid Synthesis in Winter Wheat Roots and Frost Hardening by BASF 13-338, a Derivative of Pyridazinone.

9. Inhibition of linolenic Acid synthesis and modification of chilling resistance in cotton seedlings.

10. Effect of dietary fats on arachidonic acid and eicosapentaenoic acid biosynthesis and conversion to C22 fatty acids in isolated rat liver cells.

1. Modulation of fatty acid incorporation and desaturation by trifluoperazine in fungi.