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Literature DB >> 4054169

Hypocalcaemia induced by glucocorticoids in a child with hypoparathyroidism treated with 1-alpha-hydroxyvitamin D3.

P Vardi, A Benderly, A Etzioni, J Levy, Z Hochberg.

Abstract

Glucocorticoids tend to lower the intestinal absorption of calcium, leading to a negative calcium balance. A 7-year-old girl with hypoparathyroidism was maintained as normocalcaemic on 1-alpha-hydroxyvitamin D3 (1 alpha D3) and calcium gluconate lactate. During an episode of aplastic anaemia she was treated with prednisolone, with a subsequent dramatic fall of serum calcium despite 1 alpha D3 treatment and serum 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) in the high-normal range. Glucocorticoids seem to have interfered directly with cellular events responsible for intestinal absorption of calcium.

Entities: Chemical Disease Species

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Year: 1985 PMID： 4054169 DOI： 10.1007/BF00451962

Source DB: PubMed Journal: Eur J Pediatr ISSN： 0340-6199 Impact factor: 3.183

14 in total

Hypocalcaemia induced by glucocorticoids in a child with hypoparathyroidism treated with 1-alpha-hydroxyvitamin D3.

1. Cortisol enhancement of PTH-stimulated cyclic AMP accumulation in cultured fetal rat long bone rudiments.

2. Effect of glucocorticoids on function of the parathyroid glands in man.

3. Serum 25-hydroxyvitamin D concentrations in patients receiving chronic corticosteroid therapy.

4. Interrelationship of parathyroid and adrenocortical function in calcium homeostasis in the rat.

5. Effect of dexamethasone on calcium metabolism and 47Ca kinetics in normal subjects.

6. Inadequate status and impaired metabolism of vitamin D in the elderly.

7. Skeletal metabolism and body composition in Cushing's syndrome.

8. Altered mineral metabolism in glucocorticoid-induced osteopenia. Effect of 25-hydroxyvitamin D administration.

9. Reduction of serum-1, 25-dihydroxyvitamin-D3 in children receiving glucocorticoids.

10. Calcium and phosphorus homeostasis in man. Effect of corticosteroids.

1. Steroid-induced hypocalcaemia with tetany in a patient with hypoparathyroidism.

Review 2. A review of drug-induced hypocalcemia.

3. Interactions between growth hormone and dexamethasone in skeletal growth and bone structure of the young mouse.

4. Transient Hypocalcemia in a Dialysis Patient With Paget's disease and Presumed Renal Cell Carcinoma.