Literature DB >> 228821

Cortisol enhancement of PTH-stimulated cyclic AMP accumulation in cultured fetal rat long bone rudiments.

T J Hahn, L R Halstead.   

Abstract

Cortisol in concentrations from 10 nM to 10 microM produced a dose-related inhibition of basal and PTH1-stimulated 45Ca and [3H]-hydroxyproline release from cultured fetal rat forelimb rudiments. PTH-stimulated cyclic AMP generation however was not diminished by cortisol; in contrast, at a concentration of 1 microM cortisol produced a 57% increase in PTH-stimulated bone cyclic AMP content. The stimulatory effect of cortisol on cyclic AMP content appeared to be the result of reduced phosphodiesterase activity, since this effect was not seen in the presence of 10 mM theophylline. It is concluded that cortisol inhibition of PTH-induced resorption in long bones is not accompanied by reduced cyclic AMP generation.

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Year:  1979        PMID： 228821     DOI： 10.1007/bf02408074

Source DB:  PubMed          Journal:  Calcif Tissue Int        ISSN： 0171-967X            Impact factor:   4.333


  11 in total

1.  Glucocorticoid inhibition of protein synthesis in vivo and in vitro.

Authors:  Y S Kim; Y Kim
Journal:  J Biol Chem       Date:  1975-03-25       Impact factor: 5.157

2.  Interaction of diphenylhydantoin (phenytoin) and phenobarbital with hormonal mediation of fetal rat bone resorption in vitro.

Authors:  T J Hahn; C R Scharp; C A Richardson; L R Halstead; A J Kahn; S L Teitelbaum
Journal:  J Clin Invest       Date:  1978-08       Impact factor: 14.808

3.  Failure of estrogens and androgens to inhibit bone resorption in tissue culture.

Authors:  C B Caputo; D Meadows; L G Raisz
Journal:  Endocrinology       Date:  1976-04       Impact factor: 4.736

4.  Effect of glucocorticoids on bone resorption in tissue culture.

Authors:  L G Raisz; C L Trummel; J A Wener; H Simmons
Journal:  Endocrinology       Date:  1972-04       Impact factor: 4.736

5.  The effect of parathyroid hormone on the concentration of adenosine 3',5'-monophosphate in skeletal tissue in vitro.

Authors:  L R Chase; G D Aurbach
Journal:  J Biol Chem       Date:  1970-04-10       Impact factor: 5.157

6.  Bone formation in hypercortisonism.

Authors:  J Jowsey; B L Riggs
Journal:  Acta Endocrinol (Copenh)       Date:  1970-01

7.  Corticosteroid and bone.

Authors:  W S Jee; H Z Park; W E Roberts; G H Kenner
Journal:  Am J Anat       Date:  1970-12

8.  Inhibition by steroids of parathyroid hormone-induced Ca45 release from embryonic rat bone in vitro.

Authors:  P H Stern
Journal:  J Pharmacol Exp Ther       Date:  1969-08       Impact factor: 4.030

9.  Corticosteroid-induced osteopenia.

Authors:  T J Hahn
Journal:  Arch Intern Med       Date:  1978-05-15

10.  Glucocorticoid receptors and actions in subpopulations of cultured rat bone cells. Mechanism of dexamethasone potentiation of parathyroid hormone-stimulated cyclic AMP production.

Authors:  T L Chen; D Feldman
Journal:  J Clin Invest       Date:  1979-04       Impact factor: 14.808
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  5 in total

Review 1.  Is there an effective treatment for glucocorticoid-induced osteoporosis?

Authors:  D T Villareal; R Civitelli; C Gennari; L V Avioli
Journal:  Calcif Tissue Int       Date:  1991-08       Impact factor: 4.333

2.  Increase of adenylate cyclase catalytic-unit activity by dexamethasone in rat osteoblast-like cells.

Authors:  R Rizzoli; V von Tscharner; H Fleisch
Journal:  Biochem J       Date:  1986-07-15       Impact factor: 3.857

3.  Hypocalcaemia induced by glucocorticoids in a child with hypoparathyroidism treated with 1-alpha-hydroxyvitamin D3.

Authors:  P Vardi; A Benderly; A Etzioni; J Levy; Z Hochberg
Journal:  Eur J Pediatr       Date:  1985-09       Impact factor: 3.183

4.  Modulation of PTH-stimulated cyclic AMP in cultured rodent bone cells: the effects of 1,25(OH)2 vitamin D3 and its interaction with glucocorticoids.

Authors:  T L Chen; D Feldman
Journal:  Calcif Tissue Int       Date:  1984-09       Impact factor: 4.333

5.  Phosphaturic response of hydrocortisone in the presence and the absence of parathyroid hormone.

Authors:  A Frick; I Durasin; M Neuweg
Journal:  Pflugers Arch       Date:  1981-12       Impact factor: 3.657
  5 in total

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