Literature DB >> 4043223

Endothelium removal augments vasodilation by sodium nitroprusside and sodium nitrite.

Y Shirasaki, C Su.   

Abstract

Sodium nitroprusside (3-100 nM) and sodium nitrite (0.03-1 mM) caused relaxation of the rat aortic ring segments precontracted by norepinephrine. The relaxation was significantly augmented by removal of endothelium, and this augmentation was greater in the aorta from spontaneously hypertensive rats (SHR) than Wistar Kyoto rats (WKY). The mechanism remains unknown but such augmentation may be clinically favorable to the use of nitrovasodilators.

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Year:  1985        PMID： 4043223     DOI： 10.1016/0014-2999(85)90527-8

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  34 in total

1.  Development and mechanism of a specific supersensitivity to nitrovasodilators after inhibition of vascular nitric oxide synthesis in vivo.

Authors:  S Moncada; D D Rees; R Schulz; R M Palmer
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-15       Impact factor: 11.205

2.  Mechanism of 5-hydroxytryptamine-induced coronary vasodilation assessed by direct detection of nitric oxide production in guinea-pig isolated heart.

Authors:  A J Ellwood; M J Curtis
Journal:  Br J Pharmacol       Date:  1996-10       Impact factor: 8.739

3.  Elevated guanosine 3':5'-cyclic monophosphate mediates the depression of nitrovasodilator reactivity in endothelium-intact blood vessels.

Authors:  W F Jackson; R Busse
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-09       Impact factor: 3.000

4.  Vasodilatation of arterioles by acetylcholine released from single neurones in the guinea-pig submucosal plexus.

Authors:  T O Neild; K Z Shen; A Surprenant
Journal:  J Physiol       Date:  1990-01       Impact factor: 5.182

5.  Selective inhibition by gossypol of endothelium-dependent relaxations augments relaxations to glyceryl trinitrate in rabbit coeliac artery.

Authors:  U Alheid; C Dudel; U Förstermann
Journal:  Br J Pharmacol       Date:  1987-09       Impact factor: 8.739

6.  Endothelium-derived relaxing factor (EDRF) and resistance vessels in an intact vascular bed: a microangiographic study of the rabbit isolated ear.

Authors:  T M Griffith; D H Edwards; R L Davies; T J Harrison; K T Evans
Journal:  Br J Pharmacol       Date:  1988-03       Impact factor: 8.739

7.  The effects of N omega-nitro-L-arginine methyl ester, sodium nitroprusside and noradrenaline on venous return in the anaesthetized cat.

Authors:  E A Bower; A C Law
Journal:  Br J Pharmacol       Date:  1993-04       Impact factor: 8.739

8.  Small intestinal motility in soluble guanylate cyclase alpha1 knockout mice: (Jejunal phenotyping of sGCalpha1 knockout mice).

Authors:  Ingeborg Dhaese; Gwen Vanneste; Patrick Sips; Emmanuel S Buys; Peter Brouckaert; Romain A Lefebvre
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2008-12-04       Impact factor: 3.000

9.  Mechanisms of tolerance to sodium nitroprusside in rat cultured aortic smooth muscle cells.

Authors:  A Papapetropoulos; C Y Go; F Murad; J D Catravas
Journal:  Br J Pharmacol       Date:  1996-01       Impact factor: 8.739

10.  Effects of NG-nitro-L-arginine methyl ester on vasodilator responses to acetylcholine, 5'-N-ethylcarboxamidoadenosine or salbutamol in conscious rats.

Authors:  S M Gardiner; P A Kemp; T Bennett
Journal:  Br J Pharmacol       Date:  1991-07       Impact factor: 8.739
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