Literature DB >> 4039683

Dephosphorylation suppresses the activity of neurofilament to promote tubulin polymerization.

Y Minami, H Sakai.   

Abstract

The phosphate content of neurofilament was diminished by half, from 49.4 to 22.9 nmol/mg, by treatment with alkaline phosphatase. Dephosphorylation decreased the activity of neurofilament to promote tubulin assembly. This suppression was supposed to be mainly due to dephosphorylation of the 200 kDa subunit of neurofilament. Dephosphorylation of the isolated 200 kDa subunit caused suppression of its activity to promote tubulin polymerization. These results suggest that changes in the phosphate content modulate interaction of neurofilament with tubulin.

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Year:  1985        PMID： 4039683     DOI： 10.1016/0014-5793(85)80914-5

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

1.  Effects of phosphorylation of the neurofilament L protein on filamentous structures.

Authors:  S Hisanaga; Y Gonda; M Inagaki; A Ikai; N Hirokawa
Journal:  Cell Regul       Date:  1990-01

2.  Influence of the phosphorylation state of neurofilament proteins on the interactions between purified filaments in vitro.

Authors:  J Eyer; J F Leterrier
Journal:  Biochem J       Date:  1988-06-15       Impact factor: 3.857

3.  cdc2-like kinase from rat spinal cord specifically phosphorylates KSPXK motifs in neurofilament proteins: isolation and characterization.

Authors:  K T Shetty; W T Link; H C Pant
Journal:  Proc Natl Acad Sci U S A       Date:  1993-07-15       Impact factor: 11.205

4.  Phosphorylation of native and reassembled neurofilaments composed of NF-L, NF-M, and NF-H by the catalytic subunit of cAMP-dependent protein kinase.

Authors:  S Hisanaga; Y Matsuoka; K Nishizawa; T Saito; M Inagaki; N Hirokawa
Journal:  Mol Biol Cell       Date:  1994-02       Impact factor: 4.138

5.  Expression of NF-L and NF-M in fibroblasts reveals coassembly of neurofilament and vimentin subunits.

Authors:  M J Monteiro; D W Cleveland
Journal:  J Cell Biol       Date:  1989-02       Impact factor: 10.539

6.  Expression of NF-L in both neuronal and nonneuronal cells of transgenic mice: increased neurofilament density in axons without affecting caliber.

Authors:  M J Monteiro; P N Hoffman; J D Gearhart; D W Cleveland
Journal:  J Cell Biol       Date:  1990-10       Impact factor: 10.539

7.  Characterization of dominant and recessive assembly-defective mutations in mouse neurofilament NF-M.

Authors:  P C Wong; D W Cleveland
Journal:  J Cell Biol       Date:  1990-11       Impact factor: 10.539

8.  The human mid-size neurofilament subunit: a repeated protein sequence and the relationship of its gene to the intermediate filament gene family.

Authors:  M W Myers; R A Lazzarini; V M Lee; W W Schlaepfer; D L Nelson
Journal:  EMBO J       Date:  1987-06       Impact factor: 11.598
  8 in total

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