Literature DB >> 4038891

The effect of synthetic ovarian hormones on an in vivo model of thrombosis in the rat.

H Emms, G P Lewis.   

Abstract

The effects of endogenous and exogenous, synthetic ovarian hormones on thrombus formation have been examined using an in vivo model in the rat. Thrombus formation in female rats was greatest during the di-oestrus stage of the oestrous cycle. Thrombus formation in both male and female rats was reduced following 6 weeks treatment with the oestrogen, ethynyl oestradiol whilst in females the progestogen, norethindrone acetate had no effect. These findings are in contrast to the increased risk of thromboembolic disorders reported in women taking oral contraceptives. The inhibitory effect of ethynyl oestradiol was not due to changes in blood flow but was dependent on the heparin concentration, being greatest at the highest heparin concentration used. Thrombus formation was greater in male rats than in females, a sex difference which is consistent with the higher incidence of cardiovascular disease in men than in women.

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Year:  1985        PMID： 4038891      PMCID： PMC1987224     

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  12 in total

1.  Effect of testosterone, sex and age on experimentally induced arterial thrombosis.

Authors:  A Uzunova; E Ramey; P W Ramwell
Journal:  Nature       Date:  1976-06-24       Impact factor: 49.962

2.  Increased prostacyclin-like activity in vascular tissues from rats on long-term treatment with an oestrogen-progestagen combination.

Authors:  M C Roncaglioni; G di Minno; I Reyers; G de Gaetano; M B Donati
Journal:  Thromb Res       Date:  1979       Impact factor: 3.944

3.  Influence of pregnancy and oral contraceptives on platelets in relation to coagulation and aggregation.

Authors:  F Lecompte; S Renaud
Journal:  Thromb Diath Haemorrh       Date:  1973-05-10

4.  Plasma concentration of LH, FSH, prolactin, progesterone and estradiol-17beta throughout the 4-day estrous cycle of the rat.

Authors:  R L Butcher; W E Collins; N W Fugo
Journal:  Endocrinology       Date:  1974-06       Impact factor: 4.736

5.  Oestradiol-17beta and pituitary responsiveness to luteinizing hormone releasing factor in the rat: a study using rectangular pulses of oestradiol-17beta monitored by non-chromatographic radioimmunoassay.

Authors:  S R Henderson; C Baker; G Fink
Journal:  J Endocrinol       Date:  1977-06       Impact factor: 4.286

6.  Intimal thickening in arteries of rats treated with synthetic sex hormones.

Authors:  E B Gammal
Journal:  Br J Exp Pathol       Date:  1976-04

7.  Thromboembolic disease and the steroidal content of oral contraceptives. A report to the Committee on Safety of Drugs.

Authors:  W H Inman; M P Vessey; B Westerholm; A Engelund
Journal:  Br Med J       Date:  1970-04-25

8.  Effect of 1-methyl-2-mercapto-5-(3-pyridyl)-imidazole (KC-6141), an anti-aggregating compound, on experimental thrombosis in rats.

Authors:  T Umetsu; K Sanai
Journal:  Thromb Haemost       Date:  1978-02-28       Impact factor: 5.249

9.  Prostacyclin-like activity in the female rat thoracic aorta and the inferior vena cava after ethinyloestradiol and norethisterone.

Authors:  L Karpati; F P Chow; M L Woollard; R A Hutton; P Dandona
Journal:  Clin Sci (Lond)       Date:  1980-11       Impact factor: 6.124

10.  Fibrin, red cell and platelet interactions in an experimental model of thrombosis.

Authors:  J R Smith; A M White
Journal:  Br J Pharmacol       Date:  1982-09       Impact factor: 8.739
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  8 in total

Review 1.  Sex differences in stroke: the contribution of coagulation.

Authors:  Meaghan Roy-O'Reilly; Louise D McCullough
Journal:  Exp Neurol       Date:  2014-02-19       Impact factor: 5.330

2.  Synthetic gestagens exert differential effects on arterial thrombosis and aortic gene expression in ovariectomized apolipoprotein E-deficient mice.

Authors:  T Freudenberger; R Deenen; I Kretschmer; A Zimmermann; L F Seiler; P Mayer; H-K Heim; K Köhrer; J W Fischer
Journal:  Br J Pharmacol       Date:  2014-09-05       Impact factor: 8.739

3.  Sex and hormonal influences on platelet sensitivity and coagulation in the rat.

Authors:  H Emms; G P Lewis
Journal:  Br J Pharmacol       Date:  1985-11       Impact factor: 8.739

4.  The anticoagulant, antithrombotic and haemorrhagic effect of long-term warfarin on experimental venous and arterial thrombosis in the rat.

Authors:  M MacIomhair; S M Lavelle
Journal:  Ir J Med Sci       Date:  1996 Jul-Sep       Impact factor: 1.568

5.  The roles of prostaglandin endoperoxides, thromboxane A2 and adenosine diphosphate in collagen-induced aggregation in man and the rat.

Authors:  H Emms; G P Lewis
Journal:  Br J Pharmacol       Date:  1986-01       Impact factor: 8.739

6.  PPARγ activation rescues mitochondrial function from inhibition of complex I and loss of PINK1.

Authors:  Juan Carlos Corona; Senio Campos de Souza; Michael R Duchen
Journal:  Exp Neurol       Date:  2013-12-26       Impact factor: 5.330

7.  Gender differences in response to chronic treatment with 17β-oestradiol and 17β-aminoestrogen pentolame on hemostasis in rats.

Authors:  Cristina Lemini; Ruth Jaimez; Martha Medina-Jiménez; María Estela Ávila
Journal:  Indian J Pharmacol       Date:  2012 Nov-Dec       Impact factor: 1.200

Review 8.  SEX DISPARITIES IN COVID-19 SEVERITY AND OUTCOME: ARE MEN WEAKER OR WOMEN STRONGER?

Authors:  Rosario Pivonello; Renata S Auriemma; Claudia Pivonello; Andrea M Isidori; Giovanni Corona; Annamaria Colao; Robert P Millar
Journal:  Neuroendocrinology       Date:  2020-11-26       Impact factor: 4.914
  8 in total

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