Literature DB >> 4037776

Specific inhibition of spermidine synthesis in Mycobacteria spp. by the dextro isomer of ethambutol.

L G Paulin, E E Brander, H J Pösö.   

Abstract

Only the dextro isomer of ethambutol inhibited mycobacterial spermidine synthase and spermidine biosynthesis. Inhibition of mycobacterial spermidine synthase appeared to be specific. Spermidine synthase from Mycobacterium fortuitum, which was resistant to ethambutol in vitro, required a higher concentration of ethambutol for its inhibition than the enzyme of susceptible Mycobacterium bovis.

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Year:  1985        PMID： 4037776      PMCID： PMC176332          DOI： 10.1128/AAC.28.1.157

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

Review 1.  Polyamines in rapid growth and cancer.

Authors:  J Jänne; H Pösö; A Raina
Journal:  Biochim Biophys Acta       Date:  1978-04-06

2.  Polyamines and RNA synthesis in a polyauxotrophic strain of E. coli.

Authors:  A Raina; S S Cohen
Journal:  Proc Natl Acad Sci U S A       Date:  1966-06       Impact factor: 11.205

3.  Structure-activity studies leading to ethambutol, a new type of antituberculous compound.

Authors:  R G Shepherd; C Baughn; M L Cantrall; B Goodstein; J P Thomas; R G Wilkinson
Journal:  Ann N Y Acad Sci       Date:  1966-04-20       Impact factor: 5.691

4.  Specific inhibition of spermidine synthase from mycobacteria by ethambutol.

Authors:  H Pöso; L Paulin; E Brander
Journal:  Lancet       Date:  1983-12-17       Impact factor: 79.321

5.  Adenosylmethionine decarboxylase from various organisms: relation of the putrescine activation of the enzyme to the ability of the organism to synthesize spermine.

Authors:  H Pösö; P Hannonen; J J Himberg; J Jänne
Journal:  Biochem Biophys Res Commun       Date:  1976-01-12       Impact factor: 3.575

Review 6.  Polyamines.

Authors:  C W Tabor; H Tabor
Journal:  Annu Rev Biochem       Date:  1984       Impact factor: 23.643

7.  Polyamine biosynthesis in Escherichia coli: construction of polyamine-deficient mutants.

Authors:  H Tabor
Journal:  Med Biol       Date:  1981-12

8.  GTP-insensitive ornithine decarboxylase in acetobacteria able to synthesize spermine.

Authors:  L Paulin; J Vehmaanperä; I Nykänen; H Pösö
Journal:  Biochem Biophys Res Commun       Date:  1983-07-29       Impact factor: 3.575

9.  Restriction of bacterial growth by inhibition of polyamine biosynthesis by using monofluoromethylornithine, difluoromethylarginine and dicyclohexylammonium sulphate.

Authors:  A J Bitonti; P P McCann; A Sjoerdsma
Journal:  Biochem J       Date:  1982-11-15       Impact factor: 3.857

10.  Inhibition of bacterial aminopropyltransferases by S-adenosyl-1,8-diamino-3-thiooctane and by dicyclohexylamine.

Authors:  A E Pegg; A J Bitonti; P P McCann; J K Coward
Journal:  FEBS Lett       Date:  1983-05-08       Impact factor: 4.124
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  10 in total

Review 1.  Antimicrobial susceptibility testing, drug resistance mechanisms, and therapy of infections with nontuberculous mycobacteria.

Authors:  Barbara A Brown-Elliott; Kevin A Nash; Richard J Wallace
Journal:  Clin Microbiol Rev       Date:  2012-07       Impact factor: 26.132

2.  Ethambutol resistance in Mycobacterium tuberculosis: critical role of embB mutations.

Authors:  S Sreevatsan; K E Stockbauer; X Pan; B N Kreiswirth; S L Moghazeh; W R Jacobs; A Telenti; J M Musser
Journal:  Antimicrob Agents Chemother       Date:  1997-08       Impact factor: 5.191

3.  Molecular genetic analysis of nucleotide polymorphisms associated with ethambutol resistance in human isolates of Mycobacterium tuberculosis.

Authors:  S V Ramaswamy; A G Amin; S Göksel; C E Stager; S J Dou; H El Sahly; S L Moghazeh; B N Kreiswirth; J M Musser
Journal:  Antimicrob Agents Chemother       Date:  2000-02       Impact factor: 5.191

4.  Predicting the in vivo mechanism of action for drug leads using NMR metabolomics.

Authors:  Steven Halouska; Robert J Fenton; Raúl G Barletta; Robert Powers
Journal:  ACS Chem Biol       Date:  2011-12-01       Impact factor: 5.100

5.  Mycobacterium tuberculosis embB codon 306 mutations confer moderately increased resistance to ethambutol in vitro and in vivo.

Authors:  Claudia Plinke; Kerstin Walter; Sahar Aly; Stefan Ehlers; Stefan Niemann
Journal:  Antimicrob Agents Chemother       Date:  2011-03-28       Impact factor: 5.191

Review 6.  Antimicrobial agent resistance in mycobacteria: molecular genetic insights.

Authors:  J M Musser
Journal:  Clin Microbiol Rev       Date:  1995-10       Impact factor: 26.132

7.  Ornithine decarboxylase, S-adenosyl-L-methionine decarboxylase and arginine decarboxylase from Mycobacterium bovis (BCG).

Authors:  L Paulin; E Brander; H Pösö
Journal:  Experientia       Date:  1987-02-15

8.  Biogenesis of the mycobacterial cell wall and the site of action of ethambutol.

Authors:  K Mikusová; R A Slayden; G S Besra; P J Brennan
Journal:  Antimicrob Agents Chemother       Date:  1995-11       Impact factor: 5.191

9.  A RubisCO-like protein links SAM metabolism with isoprenoid biosynthesis.

Authors:  Tobias J Erb; Bradley S Evans; Kyuil Cho; Benjamin P Warlick; Jaya Sriram; B McKay Wood; Heidi J Imker; Jonathan V Sweedler; F Robert Tabita; John A Gerlt
Journal:  Nat Chem Biol       Date:  2012-10-07       Impact factor: 15.040

10.  Characterisation of methionine adenosyltransferase from Mycobacterium smegmatis and M. tuberculosis.

Authors:  Bradley J Berger; Marvin H Knodel
Journal:  BMC Microbiol       Date:  2003-06-16       Impact factor: 3.605
  10 in total

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