Literature DB >> 4037304

Copper chelates as probes of biological systems: stable copper complexes with a macrocyclic bifunctional chelating agent.

M K Moi, C F Meares, M J McCall, W C Cole, S J DeNardo.   

Abstract

Monoclonal antibodies tagged with chelated metal ions have numerous potential applications. Here we report the synthesis of a new "bifunctional" metal chelator, 6(p-bromoacetamidobenzyl)-1,4,8,11-tetraazacyclotetradecane- N,N',N",N"' -tetraacetic acid, which can be covalently attached to proteins and which binds copper stably in human serum under physiological conditions. In contrast, other reagents based on ethylenediaminetetraacetic acid or diethylenetriaminepentaacetic acid rapidly lose copper to serum albumin under the same conditions.

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Year:  1985        PMID： 4037304     DOI： 10.1016/0003-2697(85)90653-0

Source DB:  PubMed          Journal:  Anal Biochem        ISSN： 0003-2697            Impact factor:   3.365


  27 in total

1.  Ionizable Calixarene-Crown Ethers with High Selectivity for Radium over Light Alkaline Earth Metal Ions.

Authors:  Xiaoyuan Chen; Min Ji; Darrell R Fisher; Chien M Wai
Journal:  Inorg Chem       Date:  2009-11-15       Impact factor: 5.165

Review 2.  Bifunctional coupling agents for radiolabeling of biomolecules and target-specific delivery of metallic radionuclides.

Authors:  Shuang Liu
Journal:  Adv Drug Deliv Rev       Date:  2008-04-23       Impact factor: 15.470

3.  Synthesis of a cross-bridged cyclam derivative for peptide conjugation and 64Cu radiolabeling.

Authors:  C Andrew Boswell; Celeste A S Regino; Kwamena E Baidoo; Karen J Wong; Ambika Bumb; Heng Xu; Diane E Milenic; James A Kelley; Christopher C Lai; Martin W Brechbiel
Journal:  Bioconjug Chem       Date:  2008-07-03       Impact factor: 4.774

4.  Imaging cancer using PET--the effect of the bifunctional chelator on the biodistribution of a (64)Cu-labeled antibody.

Authors:  Jason L J Dearling; Stephan D Voss; Patricia Dunning; Erin Snay; Frederic Fahey; Suzanne V Smith; James S Huston; Claude F Meares; S Ted Treves; Alan B Packard
Journal:  Nucl Med Biol       Date:  2010-10-27       Impact factor: 2.408

Review 5.  Approaches to radiolabeling of antibodies for diagnosis and therapy of cancer.

Authors:  A R Fritzberg; R W Berninger; S W Hadley; D W Wester
Journal:  Pharm Res       Date:  1988-06       Impact factor: 4.200

6.  In vitro and in vivo evaluation of ⁶⁴Cu-radiolabeled KCCYSL peptides for targeting epidermal growth factor receptor-2 in breast carcinomas.

Authors:  Senthil R Kumar; Fabio A Gallazzi; Riccardo Ferdani; Carolyn J Anderson; Thomas P Quinn; Susan L Deutscher
Journal:  Cancer Biother Radiopharm       Date:  2010-12       Impact factor: 3.099

7.  QSAR studies of copper azamacrocycles and thiosemicarbazones: MM3 parameter development and prediction of biological properties.

Authors:  Peter Wolohan; Jeongsoo Yoo; Michael J Welch; David E Reichert
Journal:  J Med Chem       Date:  2005-08-25       Impact factor: 7.446

8.  New Bifunctional Chelator p-SCN-PhPr-NE3TA for Copper-64: Synthesis, Peptidomimetic Conjugation, Radiolabeling, and Evaluation for PET Imaging.

Authors:  Yongkang Gai; Lingyi Sun; Wenqi Hui; Qin Ouyang; Carolyn J Anderson; Guangya Xiang; Xiang Ma; Dexing Zeng
Journal:  Inorg Chem       Date:  2016-06-27       Impact factor: 5.165

9.  Copper-64 radiopharmaceuticals for PET imaging of cancer: advances in preclinical and clinical research.

Authors:  Carolyn J Anderson; Riccardo Ferdani
Journal:  Cancer Biother Radiopharm       Date:  2009-08       Impact factor: 3.099

10.  Copper-64 radiolabeling and biological evaluation of bifunctional chelators for radiopharmaceutical development.

Authors:  Ravindra A De Silva; Sandeep Jain; Kimberly A Lears; Hyun-Soon Chong; Chi Soo Kang; Xiang Sun; Buck E Rogers
Journal:  Nucl Med Biol       Date:  2012-06-27       Impact factor: 2.408
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