Literature DB >> 403548

The interaction of some kynurenine pathway metabolites with 5-hydroxytryptophan and 5-hydroxytryptamine.

S L Handley, R C Miskin.   

Abstract

The kynurenine pathway metabolites kynurenine, 3-hydroxykynurenine and xanthurenic acid have been tested against 5-hydroxytryptamine (5-HT) and 5-hydroxytryptophan (5-HTP)-induced head twitches in the mouse in a dose-range of 0.5--5.0 mg/kg. Kynurenine and 3-hydroxykynurenine were highly active. Low doses caused marked potentiation of the twitch response to both 5-HT and 5-HTP with increased toxicity of 5-HT. High doses caused antagonism of both responses. Xanthurenic acid was inactive over the same dose range. The effects of kynurenine could not be duplicated in the guinea-pig ileum. The relevance of these results to the involvement of kynurenine pathway metabolites in depressive illness is discussed.

Entities:  

Mesh：

Substances：

Year:  1977        PMID： 403548     DOI： 10.1007/bf00431641

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  17 in total

1.  The effect of cortisone and hydrocortisone on the tryptophan peroxidase-oxidase activity of rat liver.

Authors:  J F THOMSON; E T MIKUTA
Journal:  Endocrinology       Date:  1954-08       Impact factor: 4.736

2.  Factors modifying the head-twitch response to 5-hydroxytryptophan.

Authors:  C S Boulton; S L Handley
Journal:  Psychopharmacologia       Date:  1973-07-19

3.  The "kynurenine shunt" and depression.

Authors:  A Mangoni
Journal:  Adv Biochem Psychopharmacol       Date:  1974

4.  Effect of cortisol on a central response to 5-hydroxytryptophan.

Authors:  S L Handley; R C Miskin
Journal:  Br J Pharmacol       Date:  1972-05       Impact factor: 8.739

5.  Disrupted 24-hour patterns of cortisol secretion in psychotic depression.

Authors:  E J Sachar; L Hellman; H P Roffwarg; F S Halpern; D K Fukushima; T F Gallagher
Journal:  Arch Gen Psychiatry       Date:  1973-01

6.  Tryptophan metabolism in affective psychoses.

Authors:  C L Cazzullo; A Mangoni; G Mascherpa
Journal:  Br J Psychiatry       Date:  1966-02       Impact factor: 9.319

7.  The determination of kynurenine in plasma.

Authors:  M H Joseph; D Risby
Journal:  Clin Chim Acta       Date:  1975-09-01       Impact factor: 3.786

8.  Tryptophan metabolism in depression.

Authors:  G Curzon; P K Bridges
Journal:  J Neurol Neurosurg Psychiatry       Date:  1970-10       Impact factor: 10.154

9.  Temperature changes produced by the injection of catecholamines and 5-hydroxytryptamine into the cerebral ventricles of the conscious mouse.

Authors:  R T Brittain; S L Handley
Journal:  J Physiol       Date:  1967-10       Impact factor: 5.182

10.  A method for assessing the effects of drugs on the central actions of 5-hydroxytryptamine.

Authors:  S J CORNE; R W PICKERING; B T WARNER
Journal:  Br J Pharmacol Chemother       Date:  1963-02
View more
  4 in total

1.  Dose-dependent dual action of kynurenine, a tryptophan metabolite, on the turnover of 5-hydroxytryptamine [proceedings].

Authors:  S E Gould; S L Handley
Journal:  Br J Pharmacol       Date:  1978-06       Impact factor: 8.739

Review 2.  Immune-mediated animal models of Tourette syndrome.

Authors:  Mady Hornig; W Ian Lipkin
Journal:  Neurosci Biobehav Rev       Date:  2013-01-10       Impact factor: 8.989

3.  The modulation of head-twitch behaviour by drugs acting on beta-adrenoceptors: evidence for the involvement of both beta 1- and beta 2-adrenoceptors.

Authors:  S L Handley; L Singh
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

4.  The effect of L-tryptophan on motor activity and its prevention by an extracerebral decarboxylase inhibitor and by 5-HT receptor blockers.

Authors:  M D Tricklebank; P N Drewitt; G Curzon
Journal:  Psychopharmacology (Berl)       Date:  1980       Impact factor: 4.530
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.