Literature DB >> 1175292

The determination of kynurenine in plasma.

M H Joseph, D Risby.   

Abstract

A method is described for the estimation of kynurenine in plasma via alkaline cleavage, extraction and diazotisation and coupling. Tryptophan interference, which is demonstrated in an earlier method, has been eliminated. Data on the specificity of the present method and the normal adult male range of fasting plasma kynurenine are presented. The time course of plasma tryptophan and kynurenine after a tryptophan load are studied in 3 subjects as an additional validation of the method, and as an example of its application. The method described is convenient and requires no complex apparatus.

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Year:  1975        PMID： 1175292     DOI： 10.1016/0009-8981(75)90163-1

Source DB:  PubMed          Journal:  Clin Chim Acta        ISSN： 0009-8981            Impact factor:   3.786


  10 in total

1.  Preliminary randomized double-blind placebo-controlled trial of tryptophan combined with fluoxetine to treat major depressive disorder: antidepressant and hypnotic effects.

Authors:  R D Levitan; J H Shen; R Jindal; H S Driver; S H Kennedy; C M Shapiro
Journal:  J Psychiatry Neurosci       Date:  2000-09       Impact factor: 6.186

2.  The determination of kynurenine by gas-liquid chromatography; evidence for its presence in rat brain [proceedings].

Authors:  M H Joseph
Journal:  Br J Pharmacol       Date:  1977-03       Impact factor: 8.739

3.  Metabolism of an oral tryptophan load by women and evidence against the induction of tryptophan pyrrolase by oral contraceptives.

Authors:  A R Green; M R Bloomfield; H F Woods; M Seed
Journal:  Br J Clin Pharmacol       Date:  1978-03       Impact factor: 4.335

4.  The effect of antidepressant drugs on plasma kynurenine in depressed patients.

Authors:  K Wood; J Harwood; A Coppen
Journal:  Psychopharmacology (Berl)       Date:  1978-12-08       Impact factor: 4.530

5.  Kynurenine metabolism in vitamin-B-6-deficient rat liver after tryptophan injection.

Authors:  F Takeuchi; Y Shibata
Journal:  Biochem J       Date:  1984-06-15       Impact factor: 3.857

6.  Metabolism of an oral tryptophan load. I: Effects of dose and pretreatment with tryptophan.

Authors:  A R Green; J K Aronson; G Curzon; H F Woods
Journal:  Br J Clin Pharmacol       Date:  1980-12       Impact factor: 4.335

7.  The interaction of some kynurenine pathway metabolites with 5-hydroxytryptophan and 5-hydroxytryptamine.

Authors:  S L Handley; R C Miskin
Journal:  Psychopharmacology (Berl)       Date:  1977-03-16       Impact factor: 4.530

8.  Tryptophan metabolism in the isolated perfused liver of the rat: effects of tryptophan concentration, hydrocortisone and allopurinol on tryptophan pyrrolase activity and kynurenine formation.

Authors:  A R Green; H F Woods; M H Joseph
Journal:  Br J Pharmacol       Date:  1976-05       Impact factor: 8.739

9.  Mechanism of decline in rat brain 5-hydroxytryptamine after induction of liver tryptophan pyrrolase by hydrocortisone: roles of tryptophan catabolism and kynurenine synthesis.

Authors:  S N Young
Journal:  Br J Pharmacol       Date:  1981-11       Impact factor: 8.739

10.  Pharmacokinetics of tryptophan, renal handling of kynurenine and the effect of nicotinamide on its appearance in plasma and urine following L-tryptophan loading of healthy subjects.

Authors:  S E Møller
Journal:  Eur J Clin Pharmacol       Date:  1981       Impact factor: 2.953
  10 in total

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