Literature DB >> 4030504

Specific inhibition of glyceraldehyde-3-phosphate dehydrogenase by koningic acid (heptelidic acid).

A Endo, K Hasumi, K Sakai, T Kanbe.   

Abstract

A sesquiterpene named koningic acid has been isolated from a strain of Trichoderma koningii as a potent inhibitor of ATP generation in the glycolytic pathway. From experiments with both cultured mouse carcinoma FM3A cells and isolated enzymes, it was shown that koningic acid is a specific inhibitor of glyceraldehyde 3-phosphate dehydrogenase that catalyzes the conversion of glyceraldehyde 3-phosphate to 3-phosphoglycerate.

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Year:  1985        PMID： 4030504     DOI： 10.7164/antibiotics.38.920

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  27 in total

1.  GAPDH enhances the aggressiveness and the vascularization of non-Hodgkin's B lymphomas via NF-κB-dependent induction of HIF-1α.

Authors:  J Chiche; S Pommier; M Beneteau; L Mondragón; O Meynet; B Zunino; A Mouchotte; E Verhoeyen; M Guyot; G Pagès; N Mounier; V Imbert; P Colosetti; D Goncalvès; S Marchetti; J Brière; M Carles; C Thieblemont; J-E Ricci
Journal:  Leukemia       Date:  2014-11-14       Impact factor: 11.528

2.  Responses of hypertrophied myocytes to reactive species: implications for glycolysis and electrophile metabolism.

Authors:  Brian E Sansbury; Daniel W Riggs; Robert E Brainard; Joshua K Salabei; Steven P Jones; Bradford G Hill
Journal:  Biochem J       Date:  2011-04-15       Impact factor: 3.857

Review 3.  Bioactive Secondary Metabolites Produced by the Fungal Endophytes of Conifers.

Authors:  Andrea A Stierle; Donald B Stierle
Journal:  Nat Prod Commun       Date:  2015-10       Impact factor: 0.986

4.  Nuclear complex of glyceraldehyde-3-phosphate dehydrogenase and DNA repair enzyme apurinic/apyrimidinic endonuclease I protect smooth muscle cells against oxidant-induced cell death.

Authors:  Xuwei Hou; Patricia Snarski; Yusuke Higashi; Tadashi Yoshida; Alexander Jurkevich; Patrick Delafontaine; Sergiy Sukhanov
Journal:  FASEB J       Date:  2017-04-12       Impact factor: 5.191

5.  A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product.

Authors:  Maria V Liberti; Ziwei Dai; Suzanne E Wardell; Joshua A Baccile; Xiaojing Liu; Xia Gao; Robert Baldi; Mahya Mehrmohamadi; Marc O Johnson; Neel S Madhukar; Alexander A Shestov; Iok I Christine Chio; Olivier Elemento; Jeffrey C Rathmell; Frank C Schroeder; Donald P McDonnell; Jason W Locasale
Journal:  Cell Metab       Date:  2017-09-14       Impact factor: 27.287

6.  Evolved resistance to partial GAPDH inhibition results in loss of the Warburg effect and in a different state of glycolysis.

Authors:  Maria V Liberti; Annamarie E Allen; Vijyendra Ramesh; Ziwei Dai; Katherine R Singleton; Zufeng Guo; Jun O Liu; Kris C Wood; Jason W Locasale
Journal:  J Biol Chem       Date:  2019-11-20       Impact factor: 5.157

7.  Sickle hemoglobin disturbs normal coupling among erythrocyte O2 content, glycolysis, and antioxidant capacity.

Authors:  Stephen C Rogers; Jerlinda G C Ross; Andre d'Avignon; Lindsey B Gibbons; Vered Gazit; Mojibade N Hassan; Dylan McLaughlin; Sherraine Griffin; Tara Neumayr; Malcolm Debaun; Michael R DeBaun; Allan Doctor
Journal:  Blood       Date:  2013-01-07       Impact factor: 22.113

Review 8.  Anticancer agents that counteract tumor glycolysis.

Authors:  Carlotta Granchi; Filippo Minutolo
Journal:  ChemMedChem       Date:  2012-06-08       Impact factor: 3.466

9.  Assessing bioenergetic function in response to oxidative stress by metabolic profiling.

Authors:  Brian P Dranka; Gloria A Benavides; Anne R Diers; Samantha Giordano; Blake R Zelickson; Colin Reily; Luyun Zou; John C Chatham; Bradford G Hill; Jianhua Zhang; Aimee Landar; Victor M Darley-Usmar
Journal:  Free Radic Biol Med       Date:  2011-08-16       Impact factor: 7.376

10.  Pentalenolactone-insensitive glyceraldehyde-3-phosphate dehydrogenase from Streptomyces arenae is closely related to GAPDH from thermostable eubacteria and plant chloroplasts.

Authors:  K U Fröhlich; R Kannwischer; M Rüdiger; D Mecke
Journal:  Arch Microbiol       Date:  1996-03       Impact factor: 2.552
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