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Literature DB >> 4027135

Lack of effect of highly purified subunit influenza vaccination on theophylline metabolism.

P A Winstanley, J Tjia, D J Back, D Hobson, A M Breckenridge.

Abstract

Plasma concentrations of theophylline, and urinary recovery of theophylline and its metabolites [1, 3-dimethyluric acid, 3-methyl xanthine and 1-methyluric acid] were measured before and after highly purified subunit influenza vaccination in seven healthy subjects, and five subjects with chronic obstructive bronchitis. No cases of theophylline toxicity were seen, and there was no increase in mean plasma theophylline concentration or significant decrease in urinary metabolite concentration after vaccination. An antibody response to vaccination was demonstrated in all subjects. Highly purified subunit influenza vaccination may be given with safety to patients on theophylline.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1985 PMID： 4027135 PMCID： PMC1400622 DOI： 10.1111/j.1365-2125.1985.tb02797.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

26 in total

1. Depression of hepatic cytochrome P-450-dependent monooxygenase systems with administered interferon inducing agents.

Authors: K W Renton; G J Mannering
Journal: Biochem Biophys Res Commun Date: 1976-11-22 Impact factor: 3.575

2. Depression of the hepatic cytochrome P-450 mono-oxygenase system by administered tilorone (2,7-bis(2-(diethylamino)ethoxy)fluoren-9-one dihydrochloride).

Authors: K W Renton; G J Mannering
Journal: Drug Metab Dispos Date: 1976 May-Jun Impact factor: 3.922

Review 3. Clinical pharmacokinetics of theophylline.

Authors: R I Ogilvie
Journal: Clin Pharmacokinet Date: 1978 Jul-Aug Impact factor: 6.447

4. Metabolism of xanthine alkaloids in man.

Authors: R N Warren
Journal: J Chromatogr Date: 1969-04-08

5. Factors affecting theophylline clearances: age, tobacco, marijuana, cirrhosis, congestive heart failure, obesity, oral contraceptives, benzodiazepines, barbiturates, and ethanol.

Authors: W J Jusko; M J Gardner; A Mangione; J J Schentag; J R Koup; J W Vance
Journal: J Pharm Sci Date: 1979-11 Impact factor: 3.534

6. Effect of interferon inducing agents (polyriboinosinic acid . polyribocytidylic acid and tilorone) on the heme turnover of hepatic cytochrome P-450.

Authors: R el Azhary; K W Renton; G J Mannering
Journal: Mol Pharmacol Date: 1980-05 Impact factor: 4.436

Lack of effect of highly purified subunit influenza vaccination on theophylline metabolism.

1. Depression of hepatic cytochrome P-450-dependent monooxygenase systems with administered interferon inducing agents.

2. Depression of the hepatic cytochrome P-450 mono-oxygenase system by administered tilorone (2,7-bis(2-(diethylamino)ethoxy)fluoren-9-one dihydrochloride).

Review 3. Clinical pharmacokinetics of theophylline.

4. Metabolism of xanthine alkaloids in man.

5. Factors affecting theophylline clearances: age, tobacco, marijuana, cirrhosis, congestive heart failure, obesity, oral contraceptives, benzodiazepines, barbiturates, and ethanol.

6. Effect of interferon inducing agents (polyriboinosinic acid . polyribocytidylic acid and tilorone) on the heme turnover of hepatic cytochrome P-450.

7. Influence of methylxanthine-containing foods on theophylline metabolism and kinetics.

8. Effects of allopurinol on theophylline metabolism and clearance.

9. BENZO(A)PYRENE AND OTHER POLYNUCLEAR HYDROCARBONS IN CHARCOAL-BROILED MEAT.

10. Altered theophylline pharmacokinetics during acute respiratory viral illness.

Review 1. Pharmacokinetic interactions between theophylline and other medication (Part II).

Review 2. Influenza vaccines. A reappraisal of their use.

3. The effect of pneumococcal vaccine on the disposition of theophylline.