Literature DB >> 4027126

Chronopharmacokinetics of paracetamol in normal subjects.

J Malan, J Moncrieff, E Bosch.   

Abstract

The chronopharmacokinetics of paracetamol was studied in six male volunteers. Serum concentrations of paracetamol were determined after a single oral dose of 1 g, on three occasions, spaced at least 1 week apart. Plasma drug concentration vs time curves were obtained after dosage at 08.00 h (Day 1), 14.00 h (Day 2) and 20.00 h (Day 3), under standardized conditions. Pharmacokinetic parameters compared were t1/2,alpha, t1/2,Z, tmax, Cmax and AUCpo. No statistically significant differences were found.

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Year:  1985        PMID： 4027126      PMCID： PMC1463861          DOI： 10.1111/j.1365-2125.1985.tb02726.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  7 in total

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Journal:  Clin Pharmacol Ther       Date:  1975-10       Impact factor: 6.875

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Journal:  J Pharm Pharmacol       Date:  1972-08       Impact factor: 3.765

Review 4.  Circadian changes of drug disposition in man.

Authors:  A Reinberg; M H Smolensky
Journal:  Clin Pharmacokinet       Date:  1982 Sep-Oct       Impact factor: 6.447

5.  Chronopharmacokinetic study of a prolonged release form of indomethacin.

Authors:  P Guissou; G Cuisinaud; G Llorca; E Lejeune; J Sassard
Journal:  Eur J Clin Pharmacol       Date:  1983       Impact factor: 2.953

6.  Circadian changes in the bioavailability and effects of indomethacin in healthy subjects.

Authors:  J Clench; A Reinberg; Z Dziewanowska; J Ghata; M Smolensky
Journal:  Eur J Clin Pharmacol       Date:  1981       Impact factor: 2.953

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Authors:  L J Lesko; D Brousseau; A T Canada; G Eastwood
Journal:  J Pharm Sci       Date:  1980-03       Impact factor: 3.534
  7 in total
  6 in total

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Authors:  K R Godfrey
Journal:  Eur J Clin Pharmacol       Date:  1989       Impact factor: 2.953

2.  Influence of the Time of Intravenous Administration of Paracetamol on its Pharmacokinetics and Ocular Disposition in Rabbits.

Authors:  Agnieszka Karbownik; Agnieszka Bienert; Włodzimierz Płotek; Tomasz Grabowski; Magdalena Cerbin-Koczorowska; Anna Wolc; Edmund Grześkowiak
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2017-06       Impact factor: 2.441

3.  Quantification of Low-Level Drug Effects Using Real-Time, in vitro Measurement of Oxygen Consumption Rate.

Authors:  Adam Neal; Austin M Rountree; Craig W Philips; Terrance J Kavanagh; Dominic P Williams; Peter Newham; Gamal Khalil; Daniel L Cook; Ian R Sweet
Journal:  Toxicol Sci       Date:  2015-09-22       Impact factor: 4.849

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Journal:  Dig Dis Sci       Date:  1993-08       Impact factor: 3.199

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Journal:  Eur J Clin Pharmacol       Date:  1990       Impact factor: 2.953

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Authors:  R H Rumble; M S Roberts; M J Denton
Journal:  Clin Pharmacokinet       Date:  1991-02       Impact factor: 6.447
  6 in total

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