Literature DB >> 2029807

Effects of posture and sleep on the pharmacokinetics of paracetamol (acetaminophen) and its metabolites.

R H Rumble1, M S Roberts, M J Denton.   

Abstract

The effects of posture and sleep on the pharmacokinetics of paracetamol (acetaminophen) 500 mg and its metabolites were studied in 8 healthy men. The mean residence times for paracetamol or its metabolites were significantly altered by change in posture or by sleep, whereas other pharmacokinetic parameters were unchanged. The change in mean residence time is consistent with a faster absorption of paracetamol during ambulation. The present data suggest that the proposed posture-related changes in volume of distribution do not exist, and that there is no pharmacokinetic basis for a headache being relieved by taking paracetamol and lying down.

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Year:  1991        PMID： 2029807     DOI： 10.2165/00003088-199120020-00007

Source DB:  PubMed          Journal:  Clin Pharmacokinet        ISSN： 0312-5963            Impact factor:   6.447


  26 in total

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